Abstract

Alpha-lipoic acidis an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of α-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, α-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique, as well as into microparticles of alginate/gelatin crosslinked with zinc ions. Encapsulation of α-lipoic acid in both cases was carried out by swelling of synthesized dried microparticles by their dipping in a solution of the active substance under strictly controlled conditions. Encapsulation efficiency of α-lipoic acid obtained in this study was up to 53.9 %. The structural interaction of α-lipoic acid with the carriers was revealed by Fourier transform infrared spectroscopy. In vitro released studies showed that controlled release of α-lipoic acid was achieved through its encapsulation into chitosan microparticles. The results of in vitro antioxidative activity assays of released α-lipoic acid indicated that antioxidant activity was preserved at a satisfactory level. These obtained results suggested that chitosan microparticles could be suitable for modeling the controlled release of α-lipoic acid.

Details

Title
Encapsulation of α-lipoic acid intochitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity
Author
Vidović, Bojana B  VIAFID ORCID Logo  ; Milašinović, Nikola Z; Knežević-Jugović, Zorica D  VIAFID ORCID Logo 
Pages
49-58
Publication year
2016
Publication date
2016
Publisher
Hemijska Industrija
ISSN
0367598X
e-ISSN
22177426
Source type
Scholarly Journal
Language of publication
Serbian; English
ProQuest document ID
1956094616
Copyright
© 2016. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.