Abstract

Metastatic spread is the mechanism in more than 90 percent of cancer deaths and current therapeutic options, such as systemic chemotherapy, are often ineffective. Here we provide a proof of principle for a novel two-pronged modality referred to as Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) having the potential to safely eradicate both primary tumors and distant metastatic foci. Using a combination of immune-checkpoint inhibition and plasmonic gold nanostar (GNS)–mediated photothermal therapy, we were able to achieve complete eradication of primary treated tumors and distant untreated tumors in some mice implanted with the MB49 bladder cancer cells. Delayed rechallenge with MB49 cancer cells injection in mice that appeared cured by SYMPHONY did not lead to new tumor formation after 60 days observation, indicating that SYMPHONY treatment induced effective long-lasting immunity against MB49 cancer cells.

Details

Title
Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers
Author
Liu, Yang 1 ; Maccarini, Paolo 2 ; Palmer, Gregory M 3 ; Wiguins Etienne 4 ; Zhao, Yulin 3 ; Chen-Ting, Lee 3 ; Ma, Xiumei 3 ; Inman, Brant A 4   VIAFID ORCID Logo  ; Vo-Dinh, Tuan 5   VIAFID ORCID Logo 

1  Department of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Chemistry, Duke University, Durham, NC, USA 
2  Department of Biomedical Engineering, Duke University, Durham, NC, USA 
3  Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA 
4  Department of Surgery, Duke University Medical Center, Durham, NC, USA 
5  Department of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Chemistry, Duke University, Durham, NC, USA; Fitzpatrick Institute of Photonics, Duke University, Durham, NC, USA 
Pages
1-6
Publication year
2017
Publication date
Aug 2017
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-017-09116-1
ProQuest document ID
1957227631
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.