Abstract

Hypertension prevalence varies between ethnic groups, possibly due to differences in genetic, environmental, and cultural determinants. Hispanic/Latino Americans are a diverse and understudied population. We performed a genome-wide association study (GWAS) of blood pressure (BP) traits in 12,278 participants from the Hispanics Community Health Study/Study of Latinos (HCHS/SOL). In the discovery phase we identified eight previously unreported BP loci. In the replication stage, we tested these loci in the 1982 Pelotas Birth Cohort Study of admixed Southern Brazilians, the COGENT-BP study of African descent, women of European descent from the Women Health Initiative (WHI), and a sample of European descent from the UK Biobank. No loci met the Bonferroni-adjusted level of statistical significance (0.0024). Two loci had marginal evidence of replication: rs78701042 (NGF) with diastolic BP (P = 0.008 in the 1982 Pelotas Birth Cohort Study), and rs7315692 (SLC5A8) with systolic BP (P = 0.007 in European ancestry replication). We investigated whether previously reported loci associated with BP in studies of European, African, and Asian ancestry generalize to Hispanics/Latinos. Overall, 26% of the known associations in studies of individuals of European and Chinese ancestries generalized, while only a single association previously discovered in a people of African descent generalized.

Details

Title
Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos
Author
Sofer, Tamar 1   VIAFID ORCID Logo  ; Wong, Quenna 1 ; Hartwig, Fernando P 2   VIAFID ORCID Logo  ; Taylor, Kent 3 ; Warren, Helen R 4 ; Evangelou, Evangelos 5 ; Cabrera, Claudia P 4 ; Levy, Daniel 6 ; Kramer, Holly 7 ; Lange, Leslie A 8 ; Horta, Bernardo L 2 ; Liang, Jingjing 9 ; Le, Thu H 10 ; Velez Edwards, Digna R 11 ; Tayo, Bamidele O 12 ; Gaulton, Kyle J 13 ; Smith, Jennifer A 14 ; Lu, Yingchang 15 ; Jensen, Richard A 16 ; Chen, Guanjie 17 ; Yanek, Lisa R 18 ; Schwander, Karen 19 ; Tajuddin, Salman M 20 ; Kim, Wonji 21 ; Kayima, James 22 ; McKenzie, Colin A 23 ; Fox, Ervin 24 ; Nalls, Michael A 25 ; Young, Hunter J 18 ; Sun, Yan 26 ; Lane, Jacqueline M 27 ; Cechova, Sylvia 10 ; Zhou, Jie 17 ; Tang, Hua 28 ; Fornage, Myriam 29 ; Musani, Solomon K 24 ; Wang, Heming 30 ; Lee, Juyoung 31 ; Adeyemo, Adebowale 17 ; Dreisbach, Albert W 24 ; Forrester, Terrence 23 ; Pei-Lun Chu 32 ; Cappola, Anne 33 ; Evans, Michele K 20 ; Morrison, Alanna C 34 ; Martin, Lisa W 35 ; Wiggins, Kerri L 16 ; Qin, Hui 26 ; Zhao, Wei 14 ; Jackson, Rebecca D 36 ; Ware, Erin B 37 ; Faul, Jessica D 38 ; Bray, Michael 11 ; Danny, Joshua C 39 ; Mosley, Thomas H 24 ; Palmas, Walter 40 ; Guo, Xiuqing 41 ; Papanicolaou, George J 42 ; Penman, Alan D 24 ; Polak, Joseph F 43 ; Rice, Kenneth 1 ; Boerwinkle, Eric 34 ; Bottinger, Erwin P 44 ; Liu, Kiang 45 ; Risch, Neil 46 ; Hunt, Steven C 47 ; Kooperberg, Charles 48 ; Zonderman, Alan B 20 ; Laurie, Cathy C 1 ; Becker, Diane M 18 ; Cai, Jianwen 49 ; Loos, Ruth J F 50 ; Psaty, Bruce M 16 ; Weir, David R 38 ; Kardia, Sharon L R 14 ; Arnett, Donna K 51 ; Won, Sungho 52 ; Edwards, Todd L 53 ; Redline, Susan 30 ; Cooper, Richard S 12 ; Rao, D C 19 ; Rotimi, Charles 17 ; Chadravarti, Aravinda 54 ; Zhu, Xiaofeng 30 ; Kerr, Kathleen F 1   VIAFID ORCID Logo  ; Reiner, Alex P 48 ; Franceschini, Nora 55 

 Department of Biostatistics, University of Washington, Seattle, WA, USA 
 Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil 
 Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research, Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA 
 William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK 
 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece 
 The Framingham Heart Study, Framingham, MA and the Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA 
 Departments of Medicine and Public Health Sciences, Loyola University Chicago, Maywood, IL, USA 
 Department of Medicine, University of Colorado Denver, Aurora, CO, USA 
 Department of Epidemiology & Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA 
10  Department of Medicine, Division of Nephrology, University of Virginia, Charlottesville, Virginia, USA 
11  Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA 
12  Department of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA 
13  Department of Pediatrics, University of California San Diego, La Jolla, California, USA 
14  Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA 
15  The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, USA; The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York City, New York, USA; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA 
16  Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology & Health Services, University of Washington, and Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA 
17  Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA 
18  Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 
19  Division of Biostatistics, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA 
20  Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA 
21  Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Republic of Korea 
22  Division of Adult Cardiology, Uganda Heart Institute, Makerere University College of Health Sciences, Kampala, Uganda; Makerere University College of Health Sciences, Kampala, Uganda 
23  Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica 
24  Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA 
25  Data Tecnica International, Glen Echo, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, Bethesda, Maryland, USA 
26  Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA 
27  Center for Human Genetic Research Massachusetts General Hospital, Boston, Massachusetts, USA; Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA 
28  Department of Genetics, Stanford University School of Medicine, Stanford, California, USA 
29  Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA 
30  Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA 
31  Division of Structural and Functional Genomics, Center for Genome Science, Korea National Institute of Health, Cheongju, Republic of Korea 
32  Department of Internal Medicine, Graduate Institute of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic Univerisity, New Taipei City, Taiwan, China 
33  Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA 
34  Human Genetics, Center, School of Public Health, University of Texas Health Science Center, Houston, Texas, USA 
35  Cardiovascular Institute, The George Washington University, Washington DC, USA 
36  Department of Internal Medicine, Ohio State University, Columbus, Ohio, USA 
37  Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA; Survey Research Center, Institute for Social Research, University of Michigan Ann Arbor, Michigan, USA 
38  Survey Research Center, Institute for Social Research, University of Michigan Ann Arbor, Michigan, USA 
39  Department of Biomedical Informatics, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA 
40  Department of Medicine, Columbia University, New York City, New York, USA 
41  Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, USA 
42  Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA 
43  Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA 
44  The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, USA 
45  Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois, USA 
46  Institute for Human Genetics, University of California, San Francisco, California, USA 
47  Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, USA 
48  Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA 
49  Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA 
50  The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, USA; The Genetics of Obesity and Related Metabolic Traits Program, Ichan School of Medicine at Mount Sinai, New York City, New York, USA; The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York City, New York, USA 
51  University of Kentucky, College of Public Health, Lexington, KY, USA 
52  Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Republic of Korea; Department of Public Health Science, Seoul National University, Seoul, Republic of Korea 
53  Division of Epidemiology, Department of Medicine, Institute of Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilit University Medical Center, Nashville, Tennessee, USA 
54  McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 
55  Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA 
Pages
1-12
Publication year
2017
Publication date
Sep 2017
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1957715146
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.