Abstract

Previous reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) from the UK (N = 2,869), the Nord-Trøndelag health study (HUNT) from Norway (N = 15,493), the Pelotas 1982 Birth Cohort Study from Brazil (N = 2,626), and the Swedish Sibling Health Cohort (N = 258 sibling pairs), we compared associations of maternal smoking during pregnancy and mother’s partner’s smoking during pregnancy with offspring depression and performed a discordant sibling analysis. In meta-analysis, maternal smoking during pregnancy was associated with higher odds of offspring depression (OR 1.20, 95% CI:1.08,1.34), but mother’s partner’s smoking during pregnancy was not (OR 1.05, 95% CI:0.94,1.17). However, there was only weak statistical evidence that the odds ratios for maternal and mother’s partner’s smoking differed from each other (p = 0.08). There was no clear evidence for an association between maternal smoking during pregnancy and offspring depression in the sibling analysis. Findings do not provide strong support for a causal role of maternal smoking during pregnancy in offspring depression, rather observed associations may reflect residual confounding relating to characteristics of parents who smoke.

Details

Title
Maternal Smoking in Pregnancy and Offspring Depression: a cross cohort and negative control study
Author
Taylor, Amy E 1 ; Carslake, David 2 ; Christian Loret de Mola 3 ; Rydell, Mina 4 ; Nilsen, Tom I L 5 ; Bjørngaard, Johan H 6 ; Bernardo Lessa Horta 3 ; Pearson, Rebecca 7 ; Rai, Dheeraj 7 ; Galanti, Maria Rosaria 8 ; Barros, Fernando C 9 ; Romundstad, Pål R 5 ; George Davey Smith 2 ; Munafò, Marcus R 1   VIAFID ORCID Logo 

1  MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, United Kingdom; UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, Bristol, United Kingdom 
2  MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, United Kingdom; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 
3  Federal University of Pelotas, Pelotas, Brazil 
4  Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden 
5  Department of Public Health and Nursing, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway 
6  Department of Public Health and Nursing, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Norway and Forensic Department and Research Centre Bröset, St. Olav’s University Hospital Trondheim, Trondheim, Norway 
7  Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 
8  Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden; Centre for Epidemiology and Community Medicine, Stockholm County Council, Stockholm, Sweden 
9  Federal University of Pelotas, Pelotas, Brazil; Catholic University of Pelotas, Pelotas, Brazil 
Pages
1-8
Publication year
2017
Publication date
Oct 2017
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-017-11836-3
ProQuest document ID
1957794208
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.