Abstract

Resting-state functional connectivity patterns are highly stable over time within subjects. This suggests that such ‘functional fingerprints’ may have strong genetic component. We investigated whether the functional (FC) or effective (EC) connectivity patterns of one monozygotic twin could be used to identify the co-twin among a larger sample and determined the overlap in functional fingerprints within monozygotic (MZ) twin pairs using resting state magnetoencephalography (MEG). We included 32 cognitively normal MZ twin pairs from the Netherlands Twin Register who participate in the EMIF-AD preclinAD study (average age 68 years). Combining EC information across multiple frequency bands we obtained an identification rate over 75%. Since MZ twin pairs are genetically identical these results suggest a high genetic contribution to MEG-based EC patterns, leading to large similarities in brain connectivity patterns between two individuals even after 60 years of life or more.

Details

Title
Functional and effective whole brain connectivity using magnetoencephalography to identify monozygotic twin pairs
Author
Demuru, M 1 ; Gouw, A A 2 ; Hillebrand, A 3 ; Stam, C J 3 ; van Dijk, B W 3 ; Scheltens, P 1 ; Tijms, B M 1 ; Konijnenberg, E 1 ; M ten Kate 1 ; den Braber, A 4 ; Smit, D J A 5 ; Boomsma, D I 6 ; Visser, P J 1   VIAFID ORCID Logo 

1  Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands 
2  Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; Department of Clinical Neurophysiology and Magnetoencephalography Center, VU University Medical Center, Amsterdam, The Netherlands 
3  Department of Clinical Neurophysiology and Magnetoencephalography Center, VU University Medical Center, Amsterdam, The Netherlands 
4  Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands 
5  Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands; Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands 
6  Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands 
Pages
1-11
Publication year
2017
Publication date
Aug 2017
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-017-10235-y
ProQuest document ID
1957862015
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.