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Di Zhang [1] and Chengtao Lu [1] and Zhe Yu [2] and Xiayin Wang [3] and Li Yan [3] and Juanli Zhang [1] and Hua Li [3] and Jianbo Wang [4] and Aidong Wen [1]

Academic Editor: Sharad S. Singhal

1, Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China, fmmu.edu.cn

2, Department of Pharmaceutical Analysis, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China, fmmu.edu.cn

3, Department of Natural Medicine, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China, fmmu.edu.cn

4, International Center for Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China, samsph.com

Received Jul 12, 2017; Accepted Aug 30, 2017

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

1. Introduction

As the outmost layer of the human body, the skin could be seriously damaged when constantly exposed to chemical pollutants and environmental ultraviolet (UV) radiation. UVB radiations (280–320 nm), which are one of the most damaging of the solar UV emissions, could affect various skin structures, cause edema, erythema, hyperplasia, wrinkling, roughness, and premature aging, and even lead to diagnosed skin malignancy [1]. Studies have revealed that chronic exposure of skin to UVB irradiation increases the level of reactive oxygen species (ROS) [2], which resulted in oxidative damage of cellular substrates, such as lipids, proteins, and nucleic acids, leading to inflammation, immunosuppression, apoptosis, and gene mutation [3].

Antioxidant supplementation is an effective strategy to counteract the deleterious effects of ROS generated by superoxide radical, hydroxyl radical, and singlet oxygen after UVB irradiation and reduce the harmful effect of DNA damage by excessive exposure to UVB [4]. Over the past years, there has been a growing interest in the skin care product industry in the use of natural antioxidants to inhibit the adverse effects of UVB or improve the health of irradiated skin. Phenylethanoid glycosides are very protecting promising molecules against ROS’ damaging effects, as they share the common structural group phenol, an aromatic ring linkage with at least one hydroxyl substituent. It has been reported that some phenylethanoid glycosides can be applied for photoprotection against UV-induced oxidative stress, owing to the strongest scavenging...

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