Content area
Full text
About the Authors:
Yang Liu
Contributed equally to this work with: Yang Liu, Shenyuan Xu
Roles Investigation, Methodology, Writing - original draft
Affiliations Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China, Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America
Shenyuan Xu
Contributed equally to this work with: Yang Liu, Shenyuan Xu
Roles Formal analysis, Investigation, Methodology, Software, Writing - original draft
Affiliation: Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America
ORCID http://orcid.org/0000-0002-9903-1944
Andrew L. Woodruff
Roles Methodology
Affiliation: Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America
ORCID http://orcid.org/0000-0002-5818-360X
Ming Xia
Roles Methodology, Resources
Affiliation: Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America
Ming Tan
Roles Writing - review & editing
Affiliations Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America
Michael A. Kennedy
Roles Data curation, Funding acquisition, Supervision, Writing - review & editing
* E-mail: [email protected](MAK); [email protected](XJ)
Affiliation: Department of Chemistry and Biochemistry, Miami University, Oxford, OH, United States of America
ORCID http://orcid.org/0000-0001-6462-665X
Xi Jiang
Roles Data curation, Funding acquisition, Supervision, Writing - review & editing
* E-mail: [email protected](MAK); [email protected](XJ)
Affiliations Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States of America, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America
ORCID http://orcid.org/0000-0003-1932-442XAbstract
Recognition of specific cell surface glycans, mediated by the VP8* domain of the spike protein VP4, is the essential first step in rotavirus (RV) infection. Due to lack of direct structural information of virus-ligand interactions, the molecular basis of ligand-controlled host ranges of the major human RVs (P[8] and P[4]) in P[II] genogroup remains unknown. Here, through characterization of a minor P[II] RV (P[19]) that can infect both animals (pigs) and humans, we made an important advance to fill this knowledge gap by solving the crystal structures of the P[19] VP8* in complex with its ligands. Our data showed that P[19] RVs use a novel binding site that differs from the known ones of other genotypes/genogroups. This...