Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats

Received Sep 5, 2017; Revised Oct 13, 2017; Accepted Oct 31, 2017

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1. Introduction

Wound healing is the repair of damaged skin tissue which consists of three stages, inflammation, proliferation, and remodeling [1, 2]. These stages occur at a specific time, but a number of factors such as wound type, severity, wound treatment will affect all phases of wound healing, which causes delays of wound healing [3]. In clinical practice, a wet and moist condition is needed to provide an optimum healing condition, which is regarded as a better method [4]. Nowadays, many ways such as those that contain enzymes, polysaccharides of antibacterial ointment, growth factors, and other substances have been developed; a stable, lasting, and cheaper drug is an urgent problem because of the defects of these options [5].

Dracorhodin perchlorate is an antibacterial analogs of the red pigment anthocyanin, dracorhodin is known as “Dragon’s blood” of the fruit extract of traditional Chinese drugs [6]. Dragon’s blood is well known as a traditional Chinese medicine which is processed by resin of Palm plant exudation of daemonorops DracoBL. Fruit spread over Java, Indonesia, Sumatra, Borneo, and so forth. Dragon’s blood has been used by different civilizations such as the Greeks, the Romans, and the Arabs. It has several medicinal properties, such as wound healing, cicatrizant, immunomodulator, analgesic, antiulcer, antidiarrheal, antibacterial, antiviral, antihemorrhagic, anti-inflammatory, antioxidant, mutagenic and antimutagenic, antitumor, anticancer, and cytotoxic effects [7]. Some experimental studies have shown that Dragon’s blood can promote the proliferation of fibroblasts and collagen formation and stimulate epithelium regeneration to promote wound healing.

Previous studies had demonstrated a complex effect of DP on human cells [8–12]; besides, DP has been indicated to induce apoptosis in different cell lines [6]. To identify the effective constituent in Dragon’s blood that favors wound...