Abstract

The epidemiology of classical Hodgkin lymphoma varies significantly in populations with different socioeconomic conditions. Among other changes, improvement in such conditions leads to a reduction in the association with EBV infection and predominance of the nodular sclerosis subtype. This study provides an overview of the epidemiology of 817 cases of classical Hodgkin lymphoma diagnosed in five reference hospitals of the State of Sao Paulo, Brazil, over 54 years (1954–2008). The cases were distributed in 3 periods (1954–1979; 1980–1999; and 2000–2008). EBV-positive cases decreased from 87% to 46%. In children and adolescents (<15 years) and in young adults (15–45 years), EBV-positive cases decreased respectively from 96% to 64%, and from 85% to 32%. The percentage of male patients declined from 80% to 58%. In older patients (>45 years), the decrease in EBV infection was not significant. Nodular Sclerosis was the most common subtype in all periods. These results support the hypothesis that, in the Brazilian State of Sao Paulo, classical Hodgkin lymphoma has changed and now shows characteristics consistent with Pattern III observed in populations that experienced a similar socioeconomic transition.

Details

Title
Frequency of EBV associated classical Hodgkin lymphoma decreases over a 54-year period in a Brazilian population
Author
Antonio Hugo Jose Froes Marques Campos 1   VIAFID ORCID Logo  ; Moreira, Adriana 1 ; Karina Braga Ribeiro 2 ; Roberto Pinto Paes 3 ; Zerbini, Maria Claudia 4 ; Aldred, Vera 3 ; de Souza, Carmino Antonio 5 ; Neto, Cristovam Scapulatempo 6 ; Soares, Fernando Augusto 7 ; Vassallo, Jose 8 

1  Department of Anatomic Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil 
2  Department of Collective Health, Irmandade da Santa Casa de Misericordia de São Paulo, São Paulo, Brazil 
3  Department of Anatomic Pathology, Irmandade da Santa Casa de Misericordia de São Paulo, São Paulo, Brazil 
4  Department of Anatomic Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil 
5  Hematology Clinics, Faculdade de Ciências Médicas da Universidade Estadual de Campinas (Unicamp), Campinas, São Paulo, Brazil 
6  Department of Anatomic Pathology, Hospital do Câncer de Barretos, São Paulo, Brazil; DASA - Diagnósticos das Américas, Barueri-SP, Brazil 
7  Department of Anatomic Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil; Pathology - D’Or Hospitals Network e Faculty of Dentristry, USP, São Paulo, Brazil 
8  Department of Anatomic Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil; Laboratory of Investigative Pathology, CIPED, Faculdade de Ciências Médicas da Universidade Estadual de Campinas (Unicamp), Campinas, São Paulo, Brazil 
Pages
1-8
Publication year
2018
Publication date
Jan 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-018-20133-6
ProQuest document ID
1992653229
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.