Content area
Abstract
Background and purpose
LGI1 antibody encephalitis is a synaptic autoimmune disorder that was first reported in 2010. To date, LGI1 antibody encephalitis is a widely-recognized disease in neurology and psychiatry. In order to aid clinical recognition of the condition, we analyze the clinical characteristics of 13 Chinese LGI1 antibody encephalitis patients.
Methods
We analyzed clinical features of patients admitted to the West China Hospital who had been diagnosed with LGI1 antibody encephalitis from 2015 to 2017.
Results
The median age of the 13 patients was 40.5years. There were 8 female patients, and 1 patient younger than 20years. The initial symptoms in 6 patients (46%) were psychiatric in nature. After treatment, 10 patients (77%) recovered gradually, and 11 patients (85%) showed improvement of psychiatric symptoms.
Conclusions
LGI1 antibody encephalitis should be suspected in patients who developed a rapid change in behavior or psychosis, seizures, or cognition. Timely diagnosis and treatment may yield favorable prognosis.