Content area
Full Text
About the Authors:
Arianna R. Means
Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing - original draft, Writing - review & editing
* E-mail: [email protected]
Affiliations Department of Global Health, University of Washington, Seattle, WA, United States, DeWorm3, Natural History Museum, London, United Kingdom
ORCID http://orcid.org/0000-0002-4087-7080
Lisette van Lieshout
Roles Data curation, Investigation, Methodology, Supervision, Writing - review & editing
Affiliation: Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
Eric Brienen
Roles Investigation, Writing - review & editing
Affiliation: Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
Krista Yuhas
Roles Formal analysis, Supervision, Writing - review & editing
Affiliation: Department of Global Health, University of Washington, Seattle, WA, United States
James P. Hughes
Roles Formal analysis, Supervision, Writing - review & editing
Affiliation: Department of Biostatistics, University of Washington, Seattle, WA, United States
Paul Ndungu
Roles Project administration, Writing - review & editing
Affiliation: Centre for Clinical Research, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
Benson Singa
Roles Investigation, Project administration, Writing - review & editing
Affiliation: Centre for Clinical Research, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
Judd L. Walson
Roles Conceptualization, Investigation, Methodology, Supervision, Writing - review & editing
Affiliations Department of Global Health, University of Washington, Seattle, WA, United States, DeWorm3, Natural History Museum, London, United Kingdom, Departments of Medicine, Pediatrics, and Epidemiology, University of Washington, Seattle, WA, United States of AmericaAbstract
Introduction
Current global helminth control guidelines focus on regular deworming of targeted populations for morbidity control. However, water, sanitation, and hygiene (WASH) interventions may also be important for reducing helminth transmission. We evaluated the impact of different potential helminth protective packages on infection prevalence, including repeated treatment with albendazole and praziquantel with and without WASH access.
Methodology/Principal findings
We conducted a cohort study nested within a randomized trial of empiric deworming of HIV-infected adults in Kenya. Helminth infections and infection intensity were diagnosed using semi-quantitative real-time PCR. We conducted a manual forward stepwise model building approach to identify if there are packages of interventions that may be protective against an STH infection of any species (combined outcome) and each helminth species individually. We conducted secondary analyses using the same approach only amongst individuals with no anthelmintis exposure. We used interaction terms to test for potential intervention...