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About the Authors:
Antonio Fabregat
Roles Investigation, Methodology, Software, Supervision, Validation, Writing - original draft, Writing - review & editing
* E-mail: [email protected] (AF); [email protected] (HH)
Affiliations European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, United Kingdom, Open Targets, Wellcome Genome Campus, Hinxton, United Kingdom
ORCID http://orcid.org/0000-0002-3288-8599
Florian Korninger
Roles Software
Affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, United Kingdom
Guilherme Viteri
Roles Software
Affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, United Kingdom
Konstantinos Sidiropoulos
Roles Writing - original draft, Writing - review & editing
Affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, United Kingdom
ORCID http://orcid.org/0000-0003-1014-967X
Pablo Marin-Garcia
Roles Writing - review & editing
Affiliations Fundación Investigación INCLIVA, Universitat de València, Valencia, Spain, Instituto de Medicina Genomica, Valencia, Spain
Peipei Ping
Roles Writing - review & editing
Affiliation: NIH BD2K Center of Excellence and Department of Physiology, Medicine and Bioinformatics, University of California, Los Angeles, California, United States of America
Guanming Wu
Roles Writing - review & editing
Affiliation: Oregon Health and Science University, Portland, Oregon, United States of America
Lincoln Stein
Roles Writing - review & editing
Affiliations Ontario Institute for Cancer Research, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, (Canada)
Peter D’Eustachio
Roles Writing - review & editing
Affiliation: NYU Langone Medical Center, New York, New York, United States of America
Henning Hermjakob
Roles Funding acquisition, Writing - review & editing
* E-mail: [email protected] (AF); [email protected] (HH)
Affiliations European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, United Kingdom, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, National Center for Protein Sciences, Beijing, China
ORCID http://orcid.org/0000-0001-8479-0262Abstract
Reactome is a free, open-source, open-data, curated and peer-reviewed knowledgebase of biomolecular pathways. One of its main priorities is to provide easy and efficient access to its high quality curated data. At present, biological pathway databases typically store their contents in relational databases. This limits access efficiency because there are performance issues associated with queries traversing highly interconnected data. The same data in a graph database can be queried more efficiently. Here we present the rationale behind the adoption of a graph database...