Details
Title
Heritable DNA methylation marks associated with susceptibility to breast cancer
Author
Joo, Jihoon E 1 ; Dowty, James G 2 ; Milne, Roger L 3
; Wong, Ee Ming 1 ; Pierre-Antoine Dugué 3 ; English, Dallas 3 ; Hopper, John L 2 ; Goldgar, David E 4 ; Giles, Graham G 3 ; Southey, Melissa C 1 ; Sexton, Adrienne 5 ; Christian, Alice 6 ; Trainer, Alison 7 ; Spigelman, Allan 8 ; Fellows, Andrew 7 ; Shelling, Andrew 9 ; De Fazio, Anna 10 ; Blackburn, Anneke 11 ; Crook, Ashley 12 ; Meiser, Bettina 13 ; Patterson, Briony 14 ; Clarke, Christine 15 ; Saunders, Christobel 16 ; Hunt, Clare 17 ; Scott, Clare 18 ; Amor, David 19 ; Marsh, Deborah 20 ; Edkins, Edward 21 ; Salisbury, Elizabeth 22 ; Haan, Eric 23 ; Neidermayr, Eveline 7 ; Macrae, Finlay 5 ; Gelareh Farshid 24 ; Lindeman, Geoff 25 ; Chenevix-Trench, Georgia 26 ; Mann, Graham 27 ; Gill, Grantley 28 ; Thorne, Heather 7 ; Campbell, Ian 7 ; Hickie, Ian 29 ; Winship, Ingrid 30 ; Goldblatt, Jack 31 ; Flanagan, James 32 ; Kollias, James 33 ; Visvader, Jane 18 ; Stone, Jennifer 34 ; Taylor, Jessica 5 ; Burke, Jo 35 ; Saunus, Jodi 36 ; Forbes, John 37 ; Beesley, Jonathan 26 ; Kirk, Judy 38 ; French, Juliet 26 ; Tucker, Kathy 39 ; Wu, Kathy 40 ; Phillips, Kelly 41 ; Lipton, Lara 42 ; Andrews, Leslie 38 ; Lobb, Elizabeth 43 ; Walker, Logan 44 ; Kentwell, Maira 5 ; Spurdle, Amanda 26 ; Cummings, Margaret 45 ; Gleeson, Margaret 46 ; Harris, Marion 47 ; Jenkins, Mark 48 ; Young, Mary Anne 49 ; Delatycki, Martin 19 ; Wallis, Mathew 50 ; Burgess, Matthew 19 ; Price, Melanie 51 ; Brown, Melissa 52 ; Bogwitz, Michael 5 ; Field, Michael 53 ; Friedlander, Michael 54 ; Gattas, Michael 55 ; Saleh, Mona 56 ; Hayward, Nick 26 ; Pachter, Nick 30 ; Cohen, Paul 57 ; Duijf, Pascal 58 ; James, Paul 5 ; Simpson, Peter 59 ; Fong, Peter 60 ; Butow, Phyllis 61 ; Williams, Rachael 39 ; Kefford, Richard 62 ; Scott, Rodney 63 ; Balleine, Rosemary 61 ; Dawson, Sarah-Jane 7 ; Lok, Sheau 64 ; Shona O’Connell 46 ; Greening, Sian 65 ; Nightingale, Sophie 7 ; Edwards, Stacey 26 ; Fox, Stephen 66 ; Sue-Anne McLachlan 67 ; Lakhani, Sunil 68 ; Thomas, Susan 69 ; Antill, Yoland 70
1 Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia
2 Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia
3 Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia
4 Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia; Huntsman Cancer Institute, Salt Lake, UT, USA
5 Familial Cancer Centre, Royal Melbourne Hospital, Parkville, VIC, Australia
6 Genetics Department, Central Region Genetics Service, Wellington Hospital, Wellington, New Zealand
7 The Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, Australia
8 Family Cancer Clinic, St Vincents Hospital, Darlinghurst, Australia
9 Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
10 Dept. Gynaecological Oncology, Westmead Institute for Cancer Research, Westmead Hospital, Westmead, NSW, Australia
11 Australian National University, P.O. Box 334 Canberra, ACT, Australia
12 Department of Clinical Genetics, Level 3E, Royal North Shore Hospital, St Leonards, NSW, Australia
13 Prince of Wales Hospital, The University of New South Wales, UNSW, Sydney, NSW, Australia
14 Clinical Genetics Service, Royal Hobart Hospital, GPO Box 1061 Hobart, TAS, Australia
15 Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
16 School of Surgery and Pathology, QE11 Medical Centre, Nedlands, WA, Australia
17 Southern Health Familial Cancer Centre, Monash Medical Centre, Special Medicine Building, Clayton, VIC, Australia
18 Walter and Eliza Hall Institute, C/o Royal Melbourne Hospital, Parkville, Australia
19 Genetic Health Services Victoria, Royal Children’s Hospital, Melbourne, VIC, Australia
20 Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia
21 Clinical Chemistry, Princess Margret Hospital for Children, Perth, WA, Australia
22 Anatomical Pathology, Prince of Wales Hospital, Randwick, NSW, Australia
23 Department of Medical Genetics, Women’s and Children’s Hospital, North Adelaide, SA, Australia
24 SA Tissue Pathology, IMVS, Adelaide, SA, Australia
25 Breast Cancer Laboratory, Walter and Eliza Hall Institute, PO Royal Melbourne, Hospital, Parkville, VIC, Australia
26 Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, QLD, Australia
27 Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead, NSW, Australia
28 Department of Surgery, Royal Adelaide Hospital, Adelaide, SA, Australia
29 Brain and Mind Centre, Camperdown, NSW, Australia
30 Department of Medicine, Royal Melbourne Hospital, Parkville, Australia
31 Genetic Services of WA, King Edward Memorial Hospital, Subiaco, WA, Australia
32 Epigenetics Unit, Department of Surgery and Oncology, Imperial College London, London, England
33 Breast Endocrine and Surgical Unit, Royal Adelaide Hospital, North Terrace, SA, Australia
34 Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, WA, Australia
35 Royal Hobart Hospital, Hobart, TAS, Australia
36 Breast Pathology, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, Herston, Qld, Australia
37 Director Surgical Oncology, University of Newcastle, Newcastle Mater Hospital, Waratah, NSW, Australia
38 Familial Cancer Service, Department of Medicine, Westmead Hospital, Westmead, NSW, Australia
39 Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, NSW, Australia
40 Family Cancer Clinic, St Vincent’s Hospital Sydney, Darlinghurst, Australia
41 Department of Medical Oncology, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia
42 Medical Oncology and Clinical Haematology Unit, Western Hospital, Footscray, VIC, Australia
43 School of Medicine, the University of Notre Dame, Kogarah, NSW, Australia
44 Department of Pathology, University of Otago, Christchurch, New Zealand
45 Department of Pathology, University of Queensland Medical School, Herston, QLD, Australia
46 Hunter Family Cancer Service, Waratah, NSW, Australia
47 Family Cancer Clinic, Monash Medical Centre, Clayton, Australia
48 Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia
49 The Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia
50 The Family Cancer Clinic, Austin Health, Heidelberg, VIC, Australia
51 Medical Psychology, University of Sydney, Sydney, Australia
52 University of Queensland, St. Lucia, QLD, Australia
53 Clinical Geneticist, Royal North Shore Hospital, St Leonards, NSW, Australia
54 Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW, Australia
55 Queensland Clinical Genetic Service, Royal Children’s Hospital, Bramston Terrace Herston, Herston, QLD, Australia
56 Centre for Genetic Education, Prince of Wales Hospital, Randwick, NSW, Australia
57 Gynaecological Cancer Research, St John of God Subiaco Hospital, Subiaco, WA, Australia
58 The University of Queensland Diamantina Institute, Brisbane, QLD, Australia
59 The University of Queensland, RBWH Campus, Herston, QLD, Australia
60 Regional Cancer and Blood Services, Auckland City Hospital, Grafton, Auckland, New Zealand
61 Medical Psychology Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
62 Department of Medical Oncology, Westmead Hospital, Westmead, NSW, Australia
63 Hunter Area Pathology Service, John Hunter Hospital, New Lambton Heights, NSW, Australia
64 Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, VIC, Australia
65 Illawarra Cancer Centre, Wollongong Hospital, South Coast Mail Centre, Wollongong, NSW, Australia
66 Pathology Department, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, Australia
67 Department of Oncology, St Vincent’s Hospital, Fitzroy, VIC, Australia
68 UQ Centre for Clinical Research, University of Queensland, The Royal Brisbane & Women’s Hospital Herston, St, Herston, Australia
69 Breast/Ovarian Cancer Risk Management Clinic, Royal Melbourne Hospital, Parkville, VIC, Australia
70 The Family Cancer Clinic, Cabrini Hospital, Malvern, VIC, Australia
; Wong, Ee Ming 1 ; Pierre-Antoine Dugué 3 ; English, Dallas 3 ; Hopper, John L 2 ; Goldgar, David E 4 ; Giles, Graham G 3 ; Southey, Melissa C 1 ; Sexton, Adrienne 5 ; Christian, Alice 6 ; Trainer, Alison 7 ; Spigelman, Allan 8 ; Fellows, Andrew 7 ; Shelling, Andrew 9 ; De Fazio, Anna 10 ; Blackburn, Anneke 11 ; Crook, Ashley 12 ; Meiser, Bettina 13 ; Patterson, Briony 14 ; Clarke, Christine 15 ; Saunders, Christobel 16 ; Hunt, Clare 17 ; Scott, Clare 18 ; Amor, David 19 ; Marsh, Deborah 20 ; Edkins, Edward 21 ; Salisbury, Elizabeth 22 ; Haan, Eric 23 ; Neidermayr, Eveline 7 ; Macrae, Finlay 5 ; Gelareh Farshid 24 ; Lindeman, Geoff 25 ; Chenevix-Trench, Georgia 26 ; Mann, Graham 27 ; Gill, Grantley 28 ; Thorne, Heather 7 ; Campbell, Ian 7 ; Hickie, Ian 29 ; Winship, Ingrid 30 ; Goldblatt, Jack 31 ; Flanagan, James 32 ; Kollias, James 33 ; Visvader, Jane 18 ; Stone, Jennifer 34 ; Taylor, Jessica 5 ; Burke, Jo 35 ; Saunus, Jodi 36 ; Forbes, John 37 ; Beesley, Jonathan 26 ; Kirk, Judy 38 ; French, Juliet 26 ; Tucker, Kathy 39 ; Wu, Kathy 40 ; Phillips, Kelly 41 ; Lipton, Lara 42 ; Andrews, Leslie 38 ; Lobb, Elizabeth 43 ; Walker, Logan 44 ; Kentwell, Maira 5 ; Spurdle, Amanda 26 ; Cummings, Margaret 45 ; Gleeson, Margaret 46 ; Harris, Marion 47 ; Jenkins, Mark 48 ; Young, Mary Anne 49 ; Delatycki, Martin 19 ; Wallis, Mathew 50 ; Burgess, Matthew 19 ; Price, Melanie 51 ; Brown, Melissa 52 ; Bogwitz, Michael 5 ; Field, Michael 53 ; Friedlander, Michael 54 ; Gattas, Michael 55 ; Saleh, Mona 56 ; Hayward, Nick 26 ; Pachter, Nick 30 ; Cohen, Paul 57 ; Duijf, Pascal 58 ; James, Paul 5 ; Simpson, Peter 59 ; Fong, Peter 60 ; Butow, Phyllis 61 ; Williams, Rachael 39 ; Kefford, Richard 62 ; Scott, Rodney 63 ; Balleine, Rosemary 61 ; Dawson, Sarah-Jane 7 ; Lok, Sheau 64 ; Shona O’Connell 46 ; Greening, Sian 65 ; Nightingale, Sophie 7 ; Edwards, Stacey 26 ; Fox, Stephen 66 ; Sue-Anne McLachlan 67 ; Lakhani, Sunil 68 ; Thomas, Susan 69 ; Antill, Yoland 70 1 Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia
2 Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia
3 Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia
4 Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia; Huntsman Cancer Institute, Salt Lake, UT, USA
5 Familial Cancer Centre, Royal Melbourne Hospital, Parkville, VIC, Australia
6 Genetics Department, Central Region Genetics Service, Wellington Hospital, Wellington, New Zealand
7 The Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, Australia
8 Family Cancer Clinic, St Vincents Hospital, Darlinghurst, Australia
9 Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
10 Dept. Gynaecological Oncology, Westmead Institute for Cancer Research, Westmead Hospital, Westmead, NSW, Australia
11 Australian National University, P.O. Box 334 Canberra, ACT, Australia
12 Department of Clinical Genetics, Level 3E, Royal North Shore Hospital, St Leonards, NSW, Australia
13 Prince of Wales Hospital, The University of New South Wales, UNSW, Sydney, NSW, Australia
14 Clinical Genetics Service, Royal Hobart Hospital, GPO Box 1061 Hobart, TAS, Australia
15 Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Sydney, NSW, Australia
16 School of Surgery and Pathology, QE11 Medical Centre, Nedlands, WA, Australia
17 Southern Health Familial Cancer Centre, Monash Medical Centre, Special Medicine Building, Clayton, VIC, Australia
18 Walter and Eliza Hall Institute, C/o Royal Melbourne Hospital, Parkville, Australia
19 Genetic Health Services Victoria, Royal Children’s Hospital, Melbourne, VIC, Australia
20 Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia
21 Clinical Chemistry, Princess Margret Hospital for Children, Perth, WA, Australia
22 Anatomical Pathology, Prince of Wales Hospital, Randwick, NSW, Australia
23 Department of Medical Genetics, Women’s and Children’s Hospital, North Adelaide, SA, Australia
24 SA Tissue Pathology, IMVS, Adelaide, SA, Australia
25 Breast Cancer Laboratory, Walter and Eliza Hall Institute, PO Royal Melbourne, Hospital, Parkville, VIC, Australia
26 Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, QLD, Australia
27 Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead, NSW, Australia
28 Department of Surgery, Royal Adelaide Hospital, Adelaide, SA, Australia
29 Brain and Mind Centre, Camperdown, NSW, Australia
30 Department of Medicine, Royal Melbourne Hospital, Parkville, Australia
31 Genetic Services of WA, King Edward Memorial Hospital, Subiaco, WA, Australia
32 Epigenetics Unit, Department of Surgery and Oncology, Imperial College London, London, England
33 Breast Endocrine and Surgical Unit, Royal Adelaide Hospital, North Terrace, SA, Australia
34 Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, WA, Australia
35 Royal Hobart Hospital, Hobart, TAS, Australia
36 Breast Pathology, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, Herston, Qld, Australia
37 Director Surgical Oncology, University of Newcastle, Newcastle Mater Hospital, Waratah, NSW, Australia
38 Familial Cancer Service, Department of Medicine, Westmead Hospital, Westmead, NSW, Australia
39 Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, NSW, Australia
40 Family Cancer Clinic, St Vincent’s Hospital Sydney, Darlinghurst, Australia
41 Department of Medical Oncology, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia
42 Medical Oncology and Clinical Haematology Unit, Western Hospital, Footscray, VIC, Australia
43 School of Medicine, the University of Notre Dame, Kogarah, NSW, Australia
44 Department of Pathology, University of Otago, Christchurch, New Zealand
45 Department of Pathology, University of Queensland Medical School, Herston, QLD, Australia
46 Hunter Family Cancer Service, Waratah, NSW, Australia
47 Family Cancer Clinic, Monash Medical Centre, Clayton, Australia
48 Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia
49 The Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia
50 The Family Cancer Clinic, Austin Health, Heidelberg, VIC, Australia
51 Medical Psychology, University of Sydney, Sydney, Australia
52 University of Queensland, St. Lucia, QLD, Australia
53 Clinical Geneticist, Royal North Shore Hospital, St Leonards, NSW, Australia
54 Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW, Australia
55 Queensland Clinical Genetic Service, Royal Children’s Hospital, Bramston Terrace Herston, Herston, QLD, Australia
56 Centre for Genetic Education, Prince of Wales Hospital, Randwick, NSW, Australia
57 Gynaecological Cancer Research, St John of God Subiaco Hospital, Subiaco, WA, Australia
58 The University of Queensland Diamantina Institute, Brisbane, QLD, Australia
59 The University of Queensland, RBWH Campus, Herston, QLD, Australia
60 Regional Cancer and Blood Services, Auckland City Hospital, Grafton, Auckland, New Zealand
61 Medical Psychology Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
62 Department of Medical Oncology, Westmead Hospital, Westmead, NSW, Australia
63 Hunter Area Pathology Service, John Hunter Hospital, New Lambton Heights, NSW, Australia
64 Department of Medical Oncology, The Royal Melbourne Hospital, Parkville, VIC, Australia
65 Illawarra Cancer Centre, Wollongong Hospital, South Coast Mail Centre, Wollongong, NSW, Australia
66 Pathology Department, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Melbourne, Australia
67 Department of Oncology, St Vincent’s Hospital, Fitzroy, VIC, Australia
68 UQ Centre for Clinical Research, University of Queensland, The Royal Brisbane & Women’s Hospital Herston, St, Herston, Australia
69 Breast/Ovarian Cancer Risk Management Clinic, Royal Melbourne Hospital, Parkville, VIC, Australia
70 The Family Cancer Clinic, Cabrini Hospital, Malvern, VIC, Australia
Pages
1-12
Publication year
2018
Publication date
Feb 2018
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2009220727
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.