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The evolutionary basis of domestication has been a longstanding question and its genetic architecture is becoming more tractable as more domestic species become genome-enabled. Before becoming established worldwide, sheep and goats were domesticated in the fertile crescent 10,500 years before present (YBP) where their wild relatives remain. Here we sequence the genomes of wild Asiatic mouflon and Bezoar ibex in the sheep and goat domestication center and compare their genomes with that of domestics from local, traditional, and improved breeds. Among the genomic regions carrying selective sweeps differentiating domestic breeds from wild populations, which are associated among others to genes involved in nervous system, immunity and productivity traits, 20 are common to Capra and Ovis. The patterns of selection vary between species, suggesting that while common targets of selection related to domestication and improvement exist, different solutions have arisen to achieve similar phenotypic end-points within these closely related livestock species.

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Title

Convergent genomic signatures of domestication in sheep and goats

Author

Alberto, Florian J¹; Boyer, Frédéric¹; Orozco-terWengel, Pablo²

; Streeter, Ian³; Servin, Bertrand⁴; de Villemereuil, Pierre⁵; Benjelloun, Badr⁶; Librado, Pablo⁷; Biscarini, Filippo⁸

; Colli, Licia⁹; Barbato, Mario¹⁰

; Zamani, Wahid¹¹; Alberti, Adriana¹²

; Engelen, Stefan¹²; Stella, Alessandra¹³; Joost, Stéphane¹⁴

; Ajmone-Marsan, Paolo⁹; Negrini, Riccardo¹⁵; Orlando, Ludovic¹⁶; Rezaei, Hamid Reza¹⁷; Naderi, Saeid¹⁸

; Clarke, Laura³

; Flicek, Paul³

; Wincker, Patrick¹⁹; Coissac, Eric¹; Kijas, James²⁰; Tosser-Klopp, Gwenola⁴

; Chikhi, Abdelkader²¹; Bruford, Michael W²²; Taberlet, Pierre¹; Pompanon, François¹

¹ Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, Grenoble, France
² School of Biosciences, Cardiff University, Museum Avenue, Cardiff, Wales, UK
³ European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
⁴ GenPhySE, INRA, INPT, ENVT, Université de Toulouse, Castanet-Tolosan, France
⁵ Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, Grenoble, France; CEFE-CNRS, UMR 5175, Montpellier 05, France
⁶ Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, Grenoble, France; Institut National de la Recherche Agronomique Maroc (INRA-Maroc), Centre Régional de Beni Mellal, Beni Mellal, Morocco
⁷ Centre for GeoGenetics, Natural History Museum of Denmark, Copenhagen, Denmark
⁸ PTP Science Park, Bioinformatics Unit, Via Einstein-Loc. Cascina Codazza, Lodi, Italy; CNR-IBBA, Milano, Italy
⁹ Istituto di Zootecnica, Facoltà di Scienze Agrarie, Alimentari e Ambientali, Università Cattolica del S. Cuore, Piacenza (PC), Italy; BioDNA - Centro di Ricerca sulla Biodiversità e DNA Antico, Facoltà di Scienze Agrarie, Alimentarie e Ambientali, Università Cattolica del S. Cuore, Piacenza (PC), Italy
¹⁰ School of Biosciences, Cardiff University, Museum Avenue, Cardiff, Wales, UK; Istituto di Zootecnica, Facoltà di Scienze Agrarie, Alimentari e Ambientali, Università Cattolica del S. Cuore, Piacenza (PC), Italy
¹¹ Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, Grenoble, France; Department of Environmental Sciences, Faculty of Natural Resources and Marine Sciences, Tarbiat Modares University, Noor, Mazandaran, Iran
¹² CEA - Institut de biologie François-Jacob, Genoscope, Evry, France
¹³ PTP Science Park, Bioinformatics Unit, Via Einstein-Loc. Cascina Codazza, Lodi, Italy
¹⁴ Laboratory of Geographic Information Systems (LASIG), School of Architecture, Civil and Environmental Engineering (ENAC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
¹⁵ BioDNA - Centro di Ricerca sulla Biodiversità e DNA Antico, Facoltà di Scienze Agrarie, Alimentarie e Ambientali, Università Cattolica del S. Cuore, Piacenza (PC), Italy; AIA Associazione Italiana Allevatori, Roma, Italy
¹⁶ Centre for GeoGenetics, Natural History Museum of Denmark, Copenhagen, Denmark; Laboratoire d’Anthropologie Moléculaire et d’Imagerie de Synthèse, CNRS UMR 5288, Université de Toulouse, Université Paul Sabatier, Toulouse, France
¹⁷ Department of Environmental Sci, Gorgan University of Agricultural Sciences & Natural Resources, Gorgan, Iran
¹⁸ Environmental Sciences Department, Natural Resources Faculty, University of Guilan, Guilan, Iran
¹⁹ CEA - Institut de biologie François-Jacob, Genoscope, Evry, France; CNRS, UMR 8030, Evry, France; Université d’Evry, UMR 8030, Evry, France
²⁰ CSIRO Agriculture, QLD, Australia
²¹ Institut National de la Recherche Agronomique Maroc (INRA-Maroc), Centre Régional d’Errachidia, Errachidia, Morocco
²² School of Biosciences, Cardiff University, Museum Avenue, Cardiff, Wales, UK; Sustainable Places Research Institute, Cardiff University, Cardiff, Wales, UK

Pages

1-9

Publication year

2018

Publication date

Mar 2018

Publisher

Nature Publishing Group

e-ISSN

20411723

Source type

Scholarly Journal

Language of publication

English

DOI

https://doi.org/10.1038/s41467-018-03206-y

ProQuest document ID

2011551202

© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Convergent genomic signatures of domestication in sheep and goats

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