In S7 Fig, the names of cell lines are incorrectly matched to the underlying data. Please see the corrected S7 Fig here.
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Copy number plots from the Cancer Cell Line Encyclopedia data.
Copy number plots show that genomic events detected in the UNC HNSCC cohort can also be found in the HNSCC cell lines from the Cancer Cell Line Encyclopedia. A. Amplifications in chromosome 3q are seen in all predicted subtypes, and the predicted classical subtype exhibits focal amplification of the region containing SOX2. B. HSC2 (predicted basal) exhibits focal amplification of EGFR, while KYSE510 (predicted atypical) does not. C. Both BIRC31 (predicted mesenchymal) and KYSE180 (predicted classical) exhibit focal deletion of CDKN2A. D. Both SCC15 (predicted mesenchymal) and PECAPJ34 (predicted basal) exhibit focal amplification of CCND1. Note that gains of 11q22 are also seen for SCC15.
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S7 Fig. Copy number plots from the Cancer Cell Line Encyclopedia data.
Copy number plots show that genomic events detected in the UNC HNSCC cohort can also be found in the HNSCC cell lines from the Cancer Cell Line Encyclopedia. A. Amplifications in chromosome 3q are seen in all predicted subtypes, and the predicted classical subtype exhibits focal amplification of the region containing SOX2. B. HSC2 (predicted basal) exhibits focal amplification of EGFR, while KYSE510 (predicted atypical) does not. C. Both BIRC31 (predicted mesenchymal) and KYSE180 (predicted classical) exhibit focal deletion of CDKN2A. D. Both SCC15 (predicted mesenchymal) and PECAPJ34 (predicted basal) exhibit focal amplification of CCND1. Note that gains of 11q22 are also seen for SCC15.
https://doi.org/10.1371/journal.pone.0194674.s001
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1. Walter V, Yin X, Wilkerson MD, Cabanski CR, Zhao N, Du Y, et al. (2013) Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes. PLoS ONE 8(2): e56823. https://doi.org/10.1371/journal.pone.0056823 pmid:23451093
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Abstract
Copy number plots show that genomic events detected in the UNC HNSCC cohort can also be found in the HNSCC cell lines from the Cancer Cell Line Encyclopedia. Copy number plots show that genomic events detected in the UNC HNSCC cohort can also be found in the HNSCC cell lines from the Cancer Cell Line Encyclopedia. (2013) Molecular Subtypes in Head and Neck Cancer Exhibit Distinct Patterns of Chromosomal Gain and Loss of Canonical Cancer Genes.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer