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About the Authors:
Vincent Mirabet
Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing - original draft, Writing - review & editing
* E-mail: [email protected] (VM); [email protected] (AB)
Affiliations Reproduction et Développement des Plantes, Univ. Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRA, F-69364 Lyon, France, Sainsbury Laboratory, University of Cambridge, Cambridge, United Kingdom
Pawel Krupinski
Roles Resources
Affiliation: Computational Biology and Biological Physics Group, Department of Theoretical Physics, Lund University, Lund, Sweden
Olivier Hamant
Roles Conceptualization, Funding acquisition, Writing - original draft, Writing - review & editing
Affiliation: Reproduction et Développement des Plantes, Univ. Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRA, F-69364 Lyon, France
ORCID http://orcid.org/0000-0001-6906-6620
Elliot M. Meyerowitz
Roles Conceptualization, Funding acquisition, Writing - review & editing
Affiliations Sainsbury Laboratory, University of Cambridge, Cambridge, United Kingdom, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, United States of America
Henrik Jönsson
Roles Conceptualization, Funding acquisition, Writing - review & editing
Affiliations Sainsbury Laboratory, University of Cambridge, Cambridge, United Kingdom, Computational Biology and Biological Physics Group, Department of Theoretical Physics, Lund University, Lund, Sweden, Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom
Arezki Boudaoud
Roles Conceptualization, Funding acquisition, Supervision, Writing - original draft, Writing - review & editing
* E-mail: [email protected] (VM); [email protected] (AB)
Affiliation: Reproduction et Développement des Plantes, Univ. Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRA, F-69364 Lyon, France
ORCID http://orcid.org/0000-0002-2780-4717Abstract
Many cell functions rely on the ability of microtubules to self-organize as complex networks. In plants, cortical microtubules are essential to determine cell shape as they guide the deposition of cellulose microfibrils, and thus control mechanical anisotropy of the cell wall. Here we analyze how, in turn, cell shape may influence microtubule behavior. Building upon previous models that confined microtubules to the cell surface, we introduce an agent model of microtubules enclosed in a three-dimensional volume. We show that the microtubule network has spontaneous aligned configurations that could explain many experimental observations without resorting to specific regulation. In particular, we find that the preferred cortical localization of microtubules emerges from directional persistence of the microtubules, and their interactions with each other and with...