Abstract

Skeletal muscle has a remarkable regenerative capacity, hich is conferred by a pool of resident stem cells, known as satellite cells. After damage, satellite cells proliferate,differentiate, and fuse to form new or repair existing multinucleated myofibers. However, after surgical or traumatic loss of a critical mass of muscle, also known as volumetric muscle loss1(VML), this endogenous regenerative competence is overwhelmed. The development of successful regenerative therapies for VML has been hindered by an incomplete under-standing of the molecular phenomena driving and mediating injury repar.

Details

Title
Robust inflammatory and fibrotic signaling following volumetric muscle loss: a barrier to muscle regeneration
Author
Larouche, Jacqueline 1   VIAFID ORCID Logo  ; Greising, Sarah M 2 ; Corona, Benjamin T 3 ; Aguilar, Carlos A 4 

1  Dept. of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Australian Regenerative Medicine Institute, Monash University, Melbourne, Australia 
2  School of Kinesiology, University of Minnesota, Minneapolis, MN, USA 
3  Wake Forest University School of Medicine, Winston-Salem, NC, USA 
4  Dept. of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA 
Pages
1-3
Publication year
2018
Publication date
Mar 2018
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41419-018-0455-7
ProQuest document ID
2019477615
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.