Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients

Jia, Bei ¹ ; Wang, Liru ² ; Claxton, David F ¹ ; Ehmann, W Christopher ¹ ; Rybka, Witold B ¹ ; Shin Mineishi ¹ ; Rizvi, Syed ³ ; Shike, Hiroko ⁴ ; Bayerl, Michael ⁴ ; Schell, Todd D ⁵ ; Hohl, Raymond J ¹ ; Zheng, Hong <sup>1 

1</sup>  Penn State Cancer Institute, Penn State University College of Medicine, Hershey, PA, USA 
²  Penn State Cancer Institute, Penn State University College of Medicine, Hershey, PA, USA; Fu Xing Hospital, Capital Medical University, Beijing, China 
³  Department of Medicine, Division of Hematology-Oncology, UT Southwestern Medical Center, Dallas, TX, USA 
⁴  Department of Pathology, Penn State University College of Medicine, Hershey, PA, USA 
⁵  Penn State Cancer Institute, Penn State University College of Medicine, Hershey, PA, USA; Depatment of Microbiology and Immunology, Penn State University College of Medicine, Hershey, PA, USA