Content area
Full Text
Dear Editor,
A 69 year-old female patient was admitted to our outpatient clinic for the tenderness of palms and soles and the thickening of the skin under the feet. These complaints lasted for three months and the pain of her feet started to cause difficulty when walking. Medical history revealed that she was on follow-up for a hepatic tumor of unknown origin for three years at oncology department. A malignant transformation was suspected and she was diagnosed hepatocellular adenocarcinoma after a liver needle biopsy 9 months ago. She was given adriamycin chemotherapy for three months. After finishing this treatment, sorafenib therapy was commenced for the last three months. Soon after the initiation of sorafenib therapy, tenderness of palms and soles started. On dermatologic examination, mild palmar erythema and hyperkeratosis along with superficial fissuring on palmar sides of the fingers were noted. Severe hyperkeratotic plaques and nodosities were found especially on lateral plantar surfaces of bilateral feet and on plantar surfaces and pulpas of the third,...