Abstract

The radiological accident in Goiania in 1987 caused a trail of human contamination, animal, plant and environmental by a radionuclide. Exposure to ionizing radiation results in different types of DNA lesions. The mutagenic effects of ionizing radiation on the germline are special concern because they can endures for several generations, leading to an increase in the rate of mutations in children of irradiated parents. Thus, to evaluate the biological mechanisms of ionizing radiation in somatic and germline cells, with consequent determination of the rate mutations, is extremely important for the estimation of genetic risks. Recently it was established that Chromosomal Microarray Analysis is an important tool for detecting wide spectra of gains or losses in the human genome. Here we present the results of the effect of accidental exposure to low doses of ionizing radiation on the formation of CNVs in the progeny of a human population accidentally exposed to Caesium-137 during the radiological accident in Goiânia, Brazil.

Details

Title
Small de novo CNVs as biomarkers of parental exposure to low doses of ionizing radiation of caesium-137
Author
Emília Oliveira Alves Costa 1 ; Irene Plaza Pinto 2   VIAFID ORCID Logo  ; Macks Wendhell Gonçalves 3 ; Juliana Ferreira da Silva 4 ; Lorraynne Guimarães Oliveira 4 ; Silva da Cruz, Alex 4 ; Daniela de Melo e Silva 5 ; da Silva, Cláudio Carlos 6 ; Pereira, Rinaldo Wellerson 7   VIAFID ORCID Logo  ; Aparecido Divino da Cruz 8   VIAFID ORCID Logo 

1  Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master’s Program, Replicon Research Group, Goiânia-GO, Brazil; Catholic University of Brasilia, Genomic Sciences and Biotechnology Graduate Program, Brasilia-DF, Brazil 
2  Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master’s Program, Replicon Research Group, Goiânia-GO, Brazil; University of Brasília, Biotechnology and Biodiversity PhD Program, Brasilia-DF, Brazil 
3  Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master’s Program, Replicon Research Group, Goiânia-GO, Brazil; Federal University of Goiás, Graduate Program in Genetics and Molecular Biology, Institute of Biological Sciences, Goiânia-GO, Brazil 
4  Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master’s Program, Replicon Research Group, Goiânia-GO, Brazil 
5  Federal University of Goiás, Graduate Program in Genetics and Molecular Biology, Institute of Biological Sciences, Goiânia-GO, Brazil 
6  Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master’s Program, Replicon Research Group, Goiânia-GO, Brazil; Human Cytogenetics and Molecular Genetics Laboratory, Health Secretary of Goiás State, Goiânia-GO, Brazil; University of Brasília, Biotechnology and Biodiversity PhD Program, Brasilia-DF, Brazil; State University of Goiás, UnU Goiania, Goiânia-GO, Brazil 
7  Catholic University of Brasilia, Genomic Sciences and Biotechnology Graduate Program, Brasilia-DF, Brazil 
8  Pontifical Catholic University of Goiás, Department of Agricultural and Biological Sciences, Genetics Master’s Program, Replicon Research Group, Goiânia-GO, Brazil; Human Cytogenetics and Molecular Genetics Laboratory, Health Secretary of Goiás State, Goiânia-GO, Brazil; University of Brasília, Biotechnology and Biodiversity PhD Program, Brasilia-DF, Brazil; Federal University of Goiás, Graduate Program in Genetics and Molecular Biology, Institute of Biological Sciences, Goiânia-GO, Brazil 
Pages
1-13
Publication year
2018
Publication date
Apr 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-018-23813-5
ProQuest document ID
2024453416
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.