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About the Authors:
Peter A. Larson
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing - original draft, Writing - review & editing
* E-mail: [email protected] (PAL); [email protected] (JVM)
Affiliation: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
John B. Moldovan
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - review & editing
Affiliation: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
Naveen Jasti
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - review & editing
Affiliation: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
Jeffrey M. Kidd
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing - review & editing
Affiliations Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
Christine R. Beck
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - original draft, Writing - review & editing
Current address: Department of Genetics and Genome Sciences, University of Connecticut Health Center & The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America
Affiliation: Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
John V. Moran
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
* E-mail: [email protected] (PAL); [email protected] (JVM)
Affiliations Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of AmericaAbstract
Human Long interspersed element-1 (L1) retrotransposons contain an internal RNA polymerase II promoter within their 5' untranslated region (UTR) and encode two proteins, (ORF1p and ORF2p) required for their mobilization (i.e., retrotransposition). The evolutionary success of L1 relies on the continuous retrotransposition of full-length L1 mRNAs. Previous studies identified functional splice donor (SD), splice acceptor (SA), and polyadenylation sequences in L1 mRNA and provided evidence that a small number of spliced...