Abstract

In this study we aimed to explore the significance of glycemic control during gestational diabetes mellitus (GDM) pregnancy in predicting recurrence as this is unknown. A retrospective population-based cohort study of women with first diagnosed GDM pregnancy was conducted. A total of 426 women with 4,226 glucose charts were obtained. Daily glucose values were collected from the glucose charts. Non-parametric (LOWESS) regression was used to present the glucose measurements along the gestational weeks. The analyses revealed that the 2-hour postprandial levels among women with GDM recurrence were substantially higher throughout gestation (PR = 1.89 [95% CI: 1.33, 2.73] for every 20 mg/dl increase). In a multivariable log-binomial regression, the mean postprandial glucose was significantly associated with GDM recurrence (p = 0.017) after adjusting for maternal age, family history of diabetes, insulin use, and inter-pregnancy interval (PR = 1.04 [95% CI: 1.01, 1.07]). The study conclusion is that tighter postprandial glycemic control should be considered. Future studies should explore tighter cutoffs of the 2-hour postprandial glucose.

Details

Title
Postprandial glycemic control during gestational diabetes pregnancy predicts the risk of recurrence
Author
Schwartz, Naama 1 ; Green, Manfred S 2 ; Yefet, Enav 3   VIAFID ORCID Logo  ; Zohar Nachum 4 

1  School of Public Health, University of Haifa, Haifa, Israel; Epidemiology & Statistics, Emek Medical Center, Afula, Israel 
2  School of Public Health, University of Haifa, Haifa, Israel 
3  Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel 
4  Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel; The Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel 
Pages
1-7
Publication year
2018
Publication date
Apr 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-018-24314-1
ProQuest document ID
2028128827
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.