Abstract

We report in this paper a new MRI contrast agent based on magnetic nanodiamonds fabricated by Fe ion implantation. The Fe atoms that are implanted into the nanodiamonds are not in direct contact with the outside world, enabling this new contrast agent to be free from cell toxicity. The image enhancement was shown clearly through T2 weighted images. The concentration dependence of the T2 relaxation time gives a relaxivity value that is about seven times that of the regular non-magnetic nanodiamonds. Cell viability study has also been performed. It was shown that they were nearly free from cytotoxicity independent of the particle concentration used. The imaging capability demonstrated here adds a new dimension to the medical application of nanodiamonds. In the future one will be able to combine this capability of magnetic nanodiamonds with other functions through surface modifications to perform drug delivery, targeted therapy, localized thermal treatment and diagnostic imaging at the same time.

Details

Title
Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
Author
Bo-Rong, Lin 1 ; Chien-Hsu, Chen 2   VIAFID ORCID Logo  ; Kunuku, Srinivasu 2 ; Chen, Tzung-Yuang 2 ; Tung-Yuan Hsiao 2 ; Niu, Huan 2   VIAFID ORCID Logo  ; Chien-Ping, Lee 1 

1  Institute of Electronics, National Chiao Tung University, Hsinchu, Taiwan 
2  Accelerator Laboratory, Nuclear Science and Technology Development Center, National Tsing Hua University, Hsinchu, Taiwan 
Pages
1-6
Publication year
2018
Publication date
May 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-018-25380-1
ProQuest document ID
2034682286
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.