Abstract

The role of the human microbiome in health and disease is increasingly appreciated. We studied the composition of microbial communities present in blood across 192 individuals, including healthy controls and patients with three disorders affecting the brain: schizophrenia, amyotrophic lateral sclerosis, and bipolar disorder. By using high-quality unmapped RNA sequencing reads as candidate microbial reads, we performed profiling of microbial transcripts detected in whole blood. We were able to detect a wide range of bacterial and archaeal phyla in blood. Interestingly, we observed an increased microbial diversity in schizophrenia patients compared to the three other groups. We replicated this finding in an independent schizophrenia case–control cohort. This increased diversity is inversely correlated with estimated cell abundance of a subpopulation of CD8+ memory T cells in healthy controls, supporting a link between microbial products found in blood, immunity and schizophrenia.

Details

Title
Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia
Author
Loes M Olde Loohuis 1   VIAFID ORCID Logo  ; Serghei Mangul 2 ; Ori, Anil P S 1 ; Jospin, Guillaume 3 ; Koslicki, David 4 ; Yang, Harry Taegyun 5   VIAFID ORCID Logo  ; Wu, Timothy 1 ; Boks, Marco P 6 ; Lomen-Hoerth, Catherine 7 ; Wiedau-Pazos, Martina 8 ; Cantor, Rita M 9 ; de Vos, Willem M 10 ; Kahn, René S 11 ; Eskin, Eleazar 5 ; Ophoff, Roel A 12 

 Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University California Los Angeles, Los Angeles, CA, USA 
 Department of Computer, Science University of California Los Angeles, Los Angeles, CA, USA; Institute for Quantitative and Computational Biosciences, University of California Los Angeles, Los Angeles, CA, USA 
 Davis Genome Center, University of California, Davis, CA, USA 
 Mathematics Department, Oregon State University, Corvallis, OR, USA 
 Department of Computer, Science University of California Los Angeles, Los Angeles, CA, USA 
 Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands 
 Department of Neurology, University of California San Francisco, San Francisco, CA, USA 
 Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA 
 Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA 
10  Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands; Department of Bacteriology and Immunology, Immunobiology Research Program, University of Helsinki, Helsinki, Finland 
11  Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA 
12  Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University California Los Angeles, Los Angeles, CA, USA; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA 
Pages
1-9
Publication year
2018
Publication date
May 2018
Publisher
Nature Publishing Group
e-ISSN
21583188
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2036770143
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.