Correction: Corticosteroid Use and Complications in a US Inflammatory Bowel Disease Cohort

Abstract

Patient characteristics of no corticosteroid and all corticosteroid users among IBD Veterans. https://doi.org/10.1371/journal.pone.0197341.t001 In Supplementary Table A of S1 Tables, the labels “UC” and “CD” are swapped in the first column. Supplementary Tables A and B provide the Veteran demographics and a detailed breakdown of the patterns of corticosteroid use for inflammatory bowel disease. Patient Characteristics (N=30,456) Total Non corticosteroids Users (NS) Continuous corticosteroid Users (CS) Intermittent corticosteroid Users (IS) Any corticosteroid Users (AS) Other corticosteroid Users (OS) p No. of Patients 30,456 (100) 20,575 (67.6) 1,438 (4.7) 240 (0.8) 4,376 (14.4) 3,827 (12.6) CD 10,664 (35.0) 7,126 (34.6) 512 (35.6) 61 (25.4) 1,610 (36.8) 1,355 (35.4) 0.001 UC 16,429 (53.9) 11,948 (58.1) 631 (43.9) 131 (54.6) 1,809 (41.3) 1,910 (49.9) <0.001 IC 3,363 (11.0) 1,501 (7.3) 295 (20.5) 48 (20.0) 957 (21.9) 562 (14.7) <0.001 Male, n (%) 28,500 (93.6) 19,389 (94.2) 1,356 (94.3) 218 (90.8) 4,022 (91.9) 3,515 (91.9) <0.001 Age, (SD) 60 ± 15 62 ± 15 a 58 ± 16 b 52 ± 17 c 52 ± 16 c 61 ± 14 d <0.001 Race, n (%) <0.001 Caucasia n 21,010 (69.0) 13,898 (67.6) 1,018 (70.8) 168 (70.0) 3,157 (72.1) 2,769 (72.4) African American 2,097 (6.9) 1,199 (5.8) 122 (8.5) 31 (12.9) 406 (9.3) 339 (8.9) Other 491 (1.6) 298 (1.4) 25 (1.7) 7 (2.9) 93 (2.1) 68 (1.8) Unknown or Missing 6,858 (22.5) 5,180 (25.2) 273 (19) 34 (14.2) 720 (16.5) 651 (17.0) Note.

In Table 1, the labels “Ulcerative Colitis” and “Crohn’s Disease” are swapped in the first column. Please see the corrected Table 1 here.

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Table 1. Patient characteristics of no corticosteroid and all corticosteroid users among IBD Veterans.

https://doi.org/10.1371/journal.pone.0197341.t001

In Supplementary Table A of S1 Tables, the labels “UC” and “CD” are swapped in the first column. Please see the correct Supplementary Table A here.

Supporting information

Showing 1/1: pone.0197341.s001.docx

Supplementary Results:

Patterns of Corticosteroid User

14.6% of Veterans on corticosteroids required continuous corticosteroids use (CS) based on

our definition, 2.4% required IS, 44.3% AS and 38.7% OS. Supplementary Tables A and B provide the

Veteran demographics and a detailed breakdown of the patterns of corticosteroid use for

inflammatory bowel disease. The IS and AS groups were younger, on average (52±17 and 52±16,

respectively), than the NS group (62±15), CS group (58±16), and OS group (61±14), p<0.001.

Corticosteroid users were more likely to have a GI visit during the study period (71.8% of CS; 80.4%

of IS; 83.3% of AS), compared to NS users (40.5% of NS), p<0.001. Furthermore, there were

significant differences in whether or not patients in the corticosteroid groups had a gastroenterology

(GI) visit within 365 days of their corticosteroid initiation date: 57.7% of CS users had a GI visit after

their corticosteroid initiation, compared to 70% of AS users and 67.5% of IS users, p<0.001.

Gastroenterology visits had a significant effect on the use of corticosteroids and the proportion of

study days spent on corticosteroids in the CS, IS, and AS groups within 365 days. CS users who had a

GI visit had a lower proportion of days on corticosteroids (median=0.14, 5

th

– 95

th

percentile: 0.03 –

0.74) compared to those who did not have a GI visit (median=0.20, 5

th

– 95

th

percentile: 0.03 – 0.90),

p<0.001. IS users with a GI visit had similar proportion of days on corticosteroids (median=0.06, 5

th

–

95

th

percentile: 0.01 – 0.26) compared to those who did not have a GI visit (median=0.05, 5

th

– 95

th

percentile: 0.01 – 0.28), p =0.654. AS users with a GI visit, on the other hand, had greater proportion

of study days on corticosteroids (median=0.05, 5

th

– 95

th

percentile: 0.007 – 0.37) than those who did

not have a GI visit (median=0.03, 5

th

– 95

th

percentile: 0.004 – 0.26), p<0.001.

Supplementary Table A: Patient Characteristics (N=30,456)

Total

Non

corticosteroids

Users (NS)

Continuous

corticosteroid

Users (CS)

Intermittent

corticosteroid

Users (IS)

Any

corticosteroid

Users (AS)

Other

corticosteroid

Users (OS)

p

No. of

Patients

30,456

(100)

20,575

(67.6)

1,438

(4.7)

240

(0.8)

4,376

(14.4)

3,827

(12.6)

CD

10,664

(35.0)

7,126

(34.6)

512

(35.6)

61

(25.4)

1,610

(36.8)

1,355

(35.4)

0.001

UC

16,429

(53.9)

11,948

(58.1)

631

(43.9)

131

(54.6)

1,809

(41.3)

1,910

(49.9)

<0.001

IC

3,363

(11.0)

1,501

(7.3)

295

(20.5)

48

(20.0)

957

(21.9)

562

(14.7)

<0.001

Male, n (%)

28,500

(93.6)

19,389 (94.2)

1,356

(94.3)

218

(90.8)

4,022

(91.9)

3,515

(91.9)

<0.001

Age, (SD)

60

± 15

62

± 15

a

58

± 16

b

52

± 17

c

52

± 16

c

61

± 14

d

<0.001

Race, n (%)

<0.001

Caucasia

n

21,010

(69.0)

13,898 (67.6)

1,018

(70.8)

168

(70.0)

3,157

(72.1)

2,769

(72.4)

African

American

2,097

(6.9)

1,199

(5.8)

122

(8.5)

31

(12.9)

406

(9.3)

339

(8.9)

Other

491

(1.6)

298

(1.4)

25

(1.7)

7

(2.9)

93

(2.1)

68

(1.8)

Unknown

or Missing

6,858

(22.5)

5,180 (25.2)

273

(19)

34

(14.2)

720

(16.5)

651

(17.0)

Note. Frequency and percent are displayed for categorical measures and mean ± standard deviation is displayed for continuous measures. Means with

different superscripts are significantly different, p<0.05, based on one-way ANOVA with Scheffe post-hoc tests.

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Supplementary results of patient characteristics and patterns of corticosteroid use.

Supplementary Table A: Patient Characteristics (N = 30,456). Supplementary Table B: Patterns of Corticosteroid user characteristics among Veteran with and without corticosteroids for IBD only.

(DOCX)

S1 Tables. Supplementary results of patient characteristics and patterns of corticosteroid use.

Supplementary Table A: Patient Characteristics (N = 30,456). Supplementary Table B: Patterns of Corticosteroid user characteristics among Veteran with and without corticosteroids for IBD only.

https://doi.org/10.1371/journal.pone.0197341.s001

(DOCX)

References

1. Waljee AK, Wiitala WL, Govani S, Stidham R, Saini S, Hou J, et al. (2016) Corticosteroid Use and Complications in a US Inflammatory Bowel Disease Cohort. PLoS ONE 11(6): e0158017. https://doi.org/10.1371/journal.pone.0158017 pmid:27336296