Details
Title
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
Author
Iglesias, Adriana I 1
; Mishra, Aniket 2 ; Vitart, Veronique 3 ; Bykhovskaya, Yelena 4 ; Höhn, René 5 ; Springelkamp, Henriët 6 ; Cuellar-Partida, Gabriel 7 ; Puya Gharahkhani 7
; Cooke Bailey, Jessica N 8
; Willoughby, Colin E 9 ; Li, Xiaohui 10
; Yazar, Seyhan 11 ; Nag, Abhishek 12 ; Khawaja, Anthony P 13
; Polašek, Ozren 14 ; Siscovick, David 15 ; Mitchell, Paul 16 ; Yih Chung Tham 17 ; Haines, Jonathan L 8
; Kearns, Lisa S 18 ; Hayward, Caroline 3
; Shi, Yuan 17 ; van Leeuwen, Elisabeth M 6 ; Taylor, Kent D 10 ; Jie Jin Wang 16 ; Rochtchina, Elena 16 ; Attia, John 19 ; Scott, Rodney 19 ; Holliday, Elizabeth G 19 ; Tien Yin Wong 18 ; Baird, Paul N 18 ; Xie, Jing 18 ; Inouye, Michael 20 ; Viswanathan, Ananth 21 ; Sim, Xueling 22 ; Bonnemaijer, Pieter 6
; Rotter, Jerome I 10 ; Martin, Nicholas G 23 ; Zeller, Tanja 24 ; Mills, Richard A 25 ; Souzeau, Emmanuelle 25 ; Staffieri, Sandra E 18
; Jonas, Jost B 26
; Schmidtmann, Irene 27 ; Boutin, Thibaud 3 ; Kang, Jae H 28
; Lucas, Sionne E M 29 ; Beutel, Manfred E 30 ; Wilson, James F 31
; R Rand Allingham 32 ; Brilliant, Murray H 33 ; Budenz, Donald L 34 ; Christen, William G 35 ; Fingert, John 36 ; Friedman, David S 37 ; Gaasterland, Douglas 38 ; Gaasterland, Terry 39 ; Hauser, Michael A 40 ; Kraft, Peter 41 ; Lee, Richard K 42 ; Lichter, Paul R 43 ; Liu, Yutao 40 ; Loomis, Stephanie J 44 ; Moroi, Sayoko E 43 ; Pericak-Vance, Margaret A 45 ; Realini, Anthony 46 ; Richards, Julia E 43 ; Schuman, Joel S 47 ; Scott, William K 45 ; Singh, Kuldev 48 ; Sit, Arthur J 49 ; Vollrath, Douglas 50 ; Weinreb, Robert N 51 ; Wollstein, Gadi 47 ; Zack, Donald J 37 ; Zhang, Kang 51 ; Donnelly, Peter 52 ; Barroso, Ines 53 ; Blackwell, Jenefer M 54 ; Bramon, Elvira 55 ; Brown, Matthew A 56 ; Casas, Juan P 57 ; Corvin, Aiden 58 ; Deloukas, Panos 53 ; Duncanson, Audrey 59 ; Jankowski, Janusz 60 ; Markus, Hugh S 61 ; Mathew, Christopher G 62 ; Palmer, Colin N A 63 ; Plomin, Robert 64 ; Rautanen, Anna 65 ; Sawcer, Stephen J 66 ; Trembath, Richard C 62 ; Wood, Nicholas W 67 ; Spencer, Chris C A 65 ; Band, Gavin 65 ; Bellenguez, Céline 65 ; Freeman, Colin 65 ; Hellenthal, Garrett 65 ; Giannoulatou, Eleni 65 ; Pirinen, Matti 65 ; Pearson, Richard 65 ; Strange, Amy 65 ; Su, Zhan 65 ; Vukcevic, Damjan 65 ; Langford, Cordelia 53 ; Hunt, Sarah E 53 ; Edkins, Sarah 53 ; Gwilliam, Rhian 53 ; Blackburn, Hannah 53 ; Bumpstead, Suzannah J 53 ; Dronov, Serge 53 ; Gillman, Matthew 53 ; Gray, Emma 53 ; Hammond, Naomi 53 ; Jayakumar, Alagurevathi 53 ; McCann, Owen T 53 ; Liddle, Jennifer 53 ; Potter, Simon C 53 ; Radhi Ravindrarajah 53 ; Ricketts, Michelle 53 ; Waller, Matthew 53 ; Weston, Paul 53 ; Widaa, Sara 53 ; Whittaker, Pamela 53 ; Uitterlinden, André G 68 ; Vithana, Eranga N 17 ; Foster, Paul J 21
; Hysi, Pirro G 12
; Hewitt, Alex W 69
; Khor, Chiea Chuen 70
; Pasquale, Louis R 71
; Montgomery, Grant W 72
; Klaver, Caroline C W 73
; Aung, Tin 74 ; Pfeiffer, Norbert 75 ; Mackey, David A 76 ; Hammond, Christopher J 12
; Ching-Yu, Cheng 74 ; Craig, Jamie E 25 ; Rabinowitz, Yaron S 4 ; Wiggs, Janey L 44
; Burdon, Kathryn P 29
; van Duijn, Cornelia M 77 ; MacGregor, Stuart 7
1 Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
2 University of Bordeaux, Bordeaux Population Health Research Center, Bordeaux, France
3 Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, Edinburgh, UK
4 Regenerative Medicine Institute and Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Cornea Genetic Eye Institute, Los Angeles, CA, USA
5 Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany; Department of Ophthalmology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland
6 Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
7 Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia
8 Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA; Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA
9 Biomedical Sciences Research Institute, Ulster University, Belfast, Northern Ireland, UK; Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK
10 Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA; Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA
11 Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, Edinburgh, UK; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, WA, Australia
12 Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK
13 Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
14 Faculty of Medicine, University of Split, Split, Croatia
15 Departments of Medicine and Epidemiology and Cardiovascular Health Research Unit, University of Washington, Washington, USA; The New York Academy of Medicine, New York, NY, USA
16 Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia
17 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
18 Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia
19 University of Newcastle, Newcastle, NSW 2308, Australia
20 Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
21 NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
22 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
23 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia
24 Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
25 Department of Ophthalmology, Flinders University, Adelaide, Australia
26 Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
27 Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, Mainz, Germany
28 Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA
29 Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia
30 Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Mainz, Germany
31 Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, Edinburgh, UK; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
32 Department of Ophthalmology, Duke University Medical Center, Durham, NC, 27705 NC, USA
33 Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA
34 Department of Ophthalmology, University of North Carolina, Chapel Hill, NC, 27517 NC, USA
35 Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
36 Department of Ophthalmology, College of Medicine, University of Iowa, Iowa City, IA, 52242 IA, USA; Department of Anatomy/Cell Biology, College of Medicine, University of Iowa, Iowa City, IA, 52242 IA, USA
37 Wilmer Eye Institute, John Hopkins University, Baltimore, MD, 21287 MD, USA
38 Eye Doctors of Washington, Chevy Chase, MD, 20815 MD, USA
39 Scripps Genome Center, University of California at San Diego, San Diego, CA, 92037 CA, USA
40 Department of Ophthalmology, Duke University Medical Center, Durham, NC, 27705 NC, USA; Department of Medicine, Duke University Medical Center, Durham, NC, 27710 NC, USA
41 Department of Biostatistics, Harvard School of Public Health, Boston, MA, 02115 MA, USA
42 Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136 FL, USA
43 Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105 MI, USA
44 Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA
45 Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, 33136 FL, USA
46 Department of Ophthalmology, WVU Eye Institute, Morgantown, WV, 26506 WV, USA
47 Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, 15213 PA, USA
48 Department of Ophthalmology, Stanford University, Palo Alto, CA, 94303 CA, USA
49 Department of Ophthalmology, Mayo Clinic, Rochester, MN, 55905 MN, USA
50 Department of Genetics, Stanford University, Palo Alto, CA, 94305 CA, USA
51 Department of Ophthalmology, Hamilton Eye Center, University of California, San Diego, CA, 92093 CA, USA
52 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Dept Statistics, University of Oxford, Oxford, UK
53 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
54 Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Subiaco, WA, Australia; Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, UK
55 Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health at the Institute of Psychiatry, King’s College London and The South London and Maudsley NHS Foundation Trust, London, UK
56 University of Queensland Diamantina Institute, Brisbane, QLD 4102, QLD, Australia
57 Dept Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK; Dept Epidemiology and Public Health, University College London, London, UK
58 Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Eire, Ireland
59 Molecular and Physiological Sciences, The Wellcome Trust, London, UK
60 Department of Oncology, Old Road Campus, University of Oxford, Oxford, UK; Digestive Diseases Centre, Leicester Royal Infirmary, Leicester, UK; Centre for Digestive Diseases, Queen Mary University of London, London, UK
61 Clinical Neurosciences, St George’s University of London, London, UK
62 King’s College London Dept Medical and Molecular Genetics, King’s Health Partners, Guy’s Hospital, London, UK
63 Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, UK
64 King’s College London Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
65 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
66 University of Cambridge Dept Clinical Neurosciences, Addenbrooke’s Hospital, Cambridge, UK
67 Dept Molecular Neuroscience, Institute of Neurology, London, UK
68 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands; Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, The Netherlands
69 Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia
70 Genome Institute of Singapore, Singapore, Singapore
71 Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA
72 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
73 Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands
74 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
75 Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
76 Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, WA, Australia
77 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
; Mishra, Aniket 2 ; Vitart, Veronique 3 ; Bykhovskaya, Yelena 4 ; Höhn, René 5 ; Springelkamp, Henriët 6 ; Cuellar-Partida, Gabriel 7 ; Puya Gharahkhani 7
; Cooke Bailey, Jessica N 8
; Willoughby, Colin E 9 ; Li, Xiaohui 10
; Yazar, Seyhan 11 ; Nag, Abhishek 12 ; Khawaja, Anthony P 13
; Polašek, Ozren 14 ; Siscovick, David 15 ; Mitchell, Paul 16 ; Yih Chung Tham 17 ; Haines, Jonathan L 8
; Kearns, Lisa S 18 ; Hayward, Caroline 3
; Shi, Yuan 17 ; van Leeuwen, Elisabeth M 6 ; Taylor, Kent D 10 ; Jie Jin Wang 16 ; Rochtchina, Elena 16 ; Attia, John 19 ; Scott, Rodney 19 ; Holliday, Elizabeth G 19 ; Tien Yin Wong 18 ; Baird, Paul N 18 ; Xie, Jing 18 ; Inouye, Michael 20 ; Viswanathan, Ananth 21 ; Sim, Xueling 22 ; Bonnemaijer, Pieter 6
; Rotter, Jerome I 10 ; Martin, Nicholas G 23 ; Zeller, Tanja 24 ; Mills, Richard A 25 ; Souzeau, Emmanuelle 25 ; Staffieri, Sandra E 18
; Jonas, Jost B 26
; Schmidtmann, Irene 27 ; Boutin, Thibaud 3 ; Kang, Jae H 28
; Lucas, Sionne E M 29 ; Beutel, Manfred E 30 ; Wilson, James F 31
; R Rand Allingham 32 ; Brilliant, Murray H 33 ; Budenz, Donald L 34 ; Christen, William G 35 ; Fingert, John 36 ; Friedman, David S 37 ; Gaasterland, Douglas 38 ; Gaasterland, Terry 39 ; Hauser, Michael A 40 ; Kraft, Peter 41 ; Lee, Richard K 42 ; Lichter, Paul R 43 ; Liu, Yutao 40 ; Loomis, Stephanie J 44 ; Moroi, Sayoko E 43 ; Pericak-Vance, Margaret A 45 ; Realini, Anthony 46 ; Richards, Julia E 43 ; Schuman, Joel S 47 ; Scott, William K 45 ; Singh, Kuldev 48 ; Sit, Arthur J 49 ; Vollrath, Douglas 50 ; Weinreb, Robert N 51 ; Wollstein, Gadi 47 ; Zack, Donald J 37 ; Zhang, Kang 51 ; Donnelly, Peter 52 ; Barroso, Ines 53 ; Blackwell, Jenefer M 54 ; Bramon, Elvira 55 ; Brown, Matthew A 56 ; Casas, Juan P 57 ; Corvin, Aiden 58 ; Deloukas, Panos 53 ; Duncanson, Audrey 59 ; Jankowski, Janusz 60 ; Markus, Hugh S 61 ; Mathew, Christopher G 62 ; Palmer, Colin N A 63 ; Plomin, Robert 64 ; Rautanen, Anna 65 ; Sawcer, Stephen J 66 ; Trembath, Richard C 62 ; Wood, Nicholas W 67 ; Spencer, Chris C A 65 ; Band, Gavin 65 ; Bellenguez, Céline 65 ; Freeman, Colin 65 ; Hellenthal, Garrett 65 ; Giannoulatou, Eleni 65 ; Pirinen, Matti 65 ; Pearson, Richard 65 ; Strange, Amy 65 ; Su, Zhan 65 ; Vukcevic, Damjan 65 ; Langford, Cordelia 53 ; Hunt, Sarah E 53 ; Edkins, Sarah 53 ; Gwilliam, Rhian 53 ; Blackburn, Hannah 53 ; Bumpstead, Suzannah J 53 ; Dronov, Serge 53 ; Gillman, Matthew 53 ; Gray, Emma 53 ; Hammond, Naomi 53 ; Jayakumar, Alagurevathi 53 ; McCann, Owen T 53 ; Liddle, Jennifer 53 ; Potter, Simon C 53 ; Radhi Ravindrarajah 53 ; Ricketts, Michelle 53 ; Waller, Matthew 53 ; Weston, Paul 53 ; Widaa, Sara 53 ; Whittaker, Pamela 53 ; Uitterlinden, André G 68 ; Vithana, Eranga N 17 ; Foster, Paul J 21
; Hysi, Pirro G 12
; Hewitt, Alex W 69
; Khor, Chiea Chuen 70
; Pasquale, Louis R 71
; Montgomery, Grant W 72
; Klaver, Caroline C W 73
; Aung, Tin 74 ; Pfeiffer, Norbert 75 ; Mackey, David A 76 ; Hammond, Christopher J 12
; Ching-Yu, Cheng 74 ; Craig, Jamie E 25 ; Rabinowitz, Yaron S 4 ; Wiggs, Janey L 44
; Burdon, Kathryn P 29
; van Duijn, Cornelia M 77 ; MacGregor, Stuart 7
1 Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
2 University of Bordeaux, Bordeaux Population Health Research Center, Bordeaux, France
3 Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, Edinburgh, UK
4 Regenerative Medicine Institute and Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Cornea Genetic Eye Institute, Los Angeles, CA, USA
5 Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany; Department of Ophthalmology, Inselspital, University Hospital Bern, University of Bern, Bern, Switzerland
6 Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
7 Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia
8 Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA; Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA
9 Biomedical Sciences Research Institute, Ulster University, Belfast, Northern Ireland, UK; Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK
10 Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA; Division of Genomic Outcomes, Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA
11 Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, Edinburgh, UK; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, WA, Australia
12 Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK
13 Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK; NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
14 Faculty of Medicine, University of Split, Split, Croatia
15 Departments of Medicine and Epidemiology and Cardiovascular Health Research Unit, University of Washington, Washington, USA; The New York Academy of Medicine, New York, NY, USA
16 Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia
17 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
18 Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia
19 University of Newcastle, Newcastle, NSW 2308, Australia
20 Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
21 NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
22 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
23 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia
24 Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
25 Department of Ophthalmology, Flinders University, Adelaide, Australia
26 Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
27 Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, Mainz, Germany
28 Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA
29 Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia
30 Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Mainz, Germany
31 Institute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, Edinburgh, UK; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
32 Department of Ophthalmology, Duke University Medical Center, Durham, NC, 27705 NC, USA
33 Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA
34 Department of Ophthalmology, University of North Carolina, Chapel Hill, NC, 27517 NC, USA
35 Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
36 Department of Ophthalmology, College of Medicine, University of Iowa, Iowa City, IA, 52242 IA, USA; Department of Anatomy/Cell Biology, College of Medicine, University of Iowa, Iowa City, IA, 52242 IA, USA
37 Wilmer Eye Institute, John Hopkins University, Baltimore, MD, 21287 MD, USA
38 Eye Doctors of Washington, Chevy Chase, MD, 20815 MD, USA
39 Scripps Genome Center, University of California at San Diego, San Diego, CA, 92037 CA, USA
40 Department of Ophthalmology, Duke University Medical Center, Durham, NC, 27705 NC, USA; Department of Medicine, Duke University Medical Center, Durham, NC, 27710 NC, USA
41 Department of Biostatistics, Harvard School of Public Health, Boston, MA, 02115 MA, USA
42 Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136 FL, USA
43 Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, 48105 MI, USA
44 Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA
45 Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, 33136 FL, USA
46 Department of Ophthalmology, WVU Eye Institute, Morgantown, WV, 26506 WV, USA
47 Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA, 15213 PA, USA
48 Department of Ophthalmology, Stanford University, Palo Alto, CA, 94303 CA, USA
49 Department of Ophthalmology, Mayo Clinic, Rochester, MN, 55905 MN, USA
50 Department of Genetics, Stanford University, Palo Alto, CA, 94305 CA, USA
51 Department of Ophthalmology, Hamilton Eye Center, University of California, San Diego, CA, 92093 CA, USA
52 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Dept Statistics, University of Oxford, Oxford, UK
53 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
54 Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Subiaco, WA, Australia; Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, UK
55 Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health at the Institute of Psychiatry, King’s College London and The South London and Maudsley NHS Foundation Trust, London, UK
56 University of Queensland Diamantina Institute, Brisbane, QLD 4102, QLD, Australia
57 Dept Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK; Dept Epidemiology and Public Health, University College London, London, UK
58 Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Eire, Ireland
59 Molecular and Physiological Sciences, The Wellcome Trust, London, UK
60 Department of Oncology, Old Road Campus, University of Oxford, Oxford, UK; Digestive Diseases Centre, Leicester Royal Infirmary, Leicester, UK; Centre for Digestive Diseases, Queen Mary University of London, London, UK
61 Clinical Neurosciences, St George’s University of London, London, UK
62 King’s College London Dept Medical and Molecular Genetics, King’s Health Partners, Guy’s Hospital, London, UK
63 Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, UK
64 King’s College London Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
65 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
66 University of Cambridge Dept Clinical Neurosciences, Addenbrooke’s Hospital, Cambridge, UK
67 Dept Molecular Neuroscience, Institute of Neurology, London, UK
68 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands; Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, The Hague, The Netherlands
69 Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia
70 Genome Institute of Singapore, Singapore, Singapore
71 Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA, USA
72 Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
73 Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands
74 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
75 Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
76 Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, WA, Australia
77 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Pages
1-11
Publication year
2018
Publication date
May 2018
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2038674406
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.