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About the Authors:
Melissa Drappier
Roles Conceptualization, Formal analysis, Investigation, Writing - original draft, Writing - review & editing
Affiliation: Université catholique de Louvain, de Duve Institute, Brussels, Belgium
Babal Kant Jha
Roles Conceptualization, Formal analysis, Investigation, Writing - original draft, Writing - review & editing
Affiliation: Translational Hematology and Oncology Research, Taussig Cancer Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
ORCID http://orcid.org/0000-0002-7660-5255
Sasha Stone
Roles Formal analysis, Investigation
Current address: Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America
Affiliation: Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
ORCID http://orcid.org/0000-0002-3596-4446
Ruth Elliott
Roles Formal analysis, Investigation
Affiliation: Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Rong Zhang
Roles Formal analysis, Investigation
Current address: Division of Infectious Diseases, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States of America
Affiliation: Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Didier Vertommen
Roles Formal analysis, Investigation, Writing - review & editing
Affiliation: Université catholique de Louvain, de Duve Institute, Brussels, Belgium
ORCID http://orcid.org/0000-0001-7648-8282
Susan R. Weiss
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing - original draft, Writing - review & editing
Affiliation: Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Robert H. Silverman
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing - original draft, Writing - review & editing
Affiliation: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
Thomas Michiels
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing - original draft, Writing - review & editing
* E-mail: [email protected]
Affiliation: Université catholique de Louvain, de Duve Institute, Brussels, Belgium
ORCID http://orcid.org/0000-0001-9615-8053Abstract
The OAS/RNase L pathway is one of the best-characterized effector pathways of the IFN antiviral response. It inhibits the replication of many viruses and ultimately promotes apoptosis of infected cells, contributing to the control of virus spread. However, viruses have evolved a range of escape strategies that act against different steps in the pathway. Here we unraveled a novel escape strategy involving...