Abstract

Objectives

To investigate the structural and functional connectivity changes of lateral geniculate nucleus (LGN) and their relationships with clinical characteristics in patients without aura.

Methods

Conventional MRI, 3D structure images and resting state functional MRI were performed in 30 migraine patients without aura (MwoA) and 22 healthy controls (HC). The lateral geniculate nucleus volumes and the functional connectivity (FC) of bilateral lateral geniculate nucleus were computed and compared between groups.

Results

The lateral geniculate nucleus volumes in patient groups did not differ from the controls. The brain regions with increased FC of the left LGN mainly located in the left cerebellum and right lingual gyrus in MwoA compared with HC. The increased FC of right LGN located in left inferior frontal gyrus in MwoA compared with HC. The correlation analysis showed a positive correlation between VLSQ-8 score and the increased FC of left cerebellum and right lingual gyrus.

Conclusions

Photophobia in MwoA could be mediated by abnormal resting state functional connectivity in visual processing regions, the pain perception regulatory network and emotion regulation network. This result is valuable to further understanding about the clinical manifestation and pathogenesis of migraine.

Details

Title
Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study
Author
Zhang, Di 1   VIAFID ORCID Logo  ; Huang, Xiaobin 1 ; Su, Wen 1 ; Chen, Yuchen 1 ; Wang, Peng 1 ; Mao Cunnan 1 ; Miao Zhengfei 1 ; Liu, Chunmei 2 ; Xu Chenjie 3 ; Yin Xindao 1 ; Wu, Xinying 1 

1  Nanjing Medical University, Department of Radiology, Nanjing First Hospital, Nanjing, China (GRID:grid.89957.3a) (ISNI:0000 0000 9255 8984) 
2  Nanjing Medical University, Department of Neurology, Nanjing First Hospital, Nanjing, China (GRID:grid.89957.3a) (ISNI:0000 0000 9255 8984) 
3  Nanjing Medical University, Department of Pain Treatment, Nanjing First Hospital, Nanjing, China (GRID:grid.89957.3a) (ISNI:0000 0000 9255 8984) 
Publication year
2020
Publication date
Dec 2020
Publisher
Springer Nature B.V.
ISSN
11292369
e-ISSN
11292377
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s10194-020-01086-6
ProQuest document ID
204091584
Copyright
The Journal of Headache and Pain is a copyright of Springer, (2020). All Rights Reserved. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.