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© 2018 Pinheiro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto.

Details

Title
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil
Author
Tauyne Menegaldo Pinheiro; Tasso de Oliveira Mota; Sakurada Aranha Watanabe; nia Paiva Drumond; Milene Rocha Ribeiro; Vedovello, Danila; Jr, jo; Paulo Filemon Paolucci Pimenta; rbara Aparecida Chaves; Marques Carneiro da Silva; Andrade Batista, Izabella Cristina; Papa, Michelle Premazzi; Lana Monteiro Meuren; alves de Oliveira Lucas; Flavio Lemos Matassoli; Helena Vega Gonzales Gil; Bozzi, Adriana; Calzavara-Silva, Carlos Eduardo; Luciana Barros de Arruda; de Souza, ria; Mauro Martins Teixeira; Vasilakis, Nikos; cio Lacerda Nogueira
Section
Research Article
Publication year
2018
Publication date
May 2018
Publisher
Public Library of Science
ISSN
19352727
e-ISSN
19352735
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2049928559
Copyright
© 2018 Pinheiro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.