Details
Title
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
Author
Ting Qi 1
; Wu, Yang 1
; Zeng, Jian 1
; Zhang, Futao 2 ; Xue, Angli 1 ; Jiang, Longda 1 ; Zhu, Zhihong 1 ; Kemper, Kathryn 1
; Yengo, Loic 1 ; Zheng, Zhili 3 ; Agbessi, Mawussé 4 ; Ahsan, Habibul 5 ; Alves, Isabel 4 ; Andiappan, Anand 6 ; Awadalla, Philip 4 ; Battle, Alexis 7 ; Beutner, Frank 8 ; Bonder, Marc Jan 9 ; Boomsma, Dorret 10 ; Christiansen, Mark 11 ; Claringbould, Annique 9 ; Deelen, Patrick 9 ; Tõnu Esko 12 ; Marie-Julie Favé 4 ; Franke, Lude 9 ; Frayling, Timothy 13 ; Gharib, Sina 14 ; Gibson, Gregory 15 ; Gibran Hemani 16 ; Jansen, Rick 10 ; Kähönen, Mika 17 ; Kalnapenkis, Anette 12 ; Silva Kasela 12 ; Kettunen, Johannes 18 ; Kim, Yungil 7 ; Kirsten, Holger 19 ; Kovacs, Peter 20 ; Krohn, Knut 21 ; Kronberg-Guzman, Jaanika 12 ; Kukushkina, Viktorija 12 ; Kutalik, Zoltan 22 ; Lee, Bernett 6 ; Lehtimäki, Terho 23 ; Loeffler, Markus 24 ; Marigorta, Urko M 15 ; Metspalu, Andres 12 ; Milani, Lili 12 ; Müller-Nurasyid, Martina 25 ; Nauck, Matthias 26 ; Nivard, Michel 10 ; Penninx, Brenda 10 ; Perola, Markus 18 ; Pervjakova, Natalia 12 ; Pierce, Brandon 5 ; Powell, Joseph 1 ; Prokisch, Holger 27 ; Psaty, Bruce 28 ; Raitakari, Olli 29 ; Ring, Susan 30 ; Ripatti, Samuli 18 ; Rotzschke, Olaf 6 ; Ruëger, Sina 22 ; Saha, Ashis 7 ; Scholz, Markus 24 ; Schramm, Katharina 25 ; Seppälä, Ilkka 23 ; Stumvoll, Michael 20 ; Sullivan, Patrick 31 ; Teumer, Alexander 32 ; Thiery, Joachim 33 ; Lin, Tong 5 ; Tönjes, Anke 34 ; Jenny van Dongen 10 ; Joyce van Meurs 35 ; Verlouw, Joost 35 ; Völker, Uwe 36 ; Võsa, Urmo 9 ; Yaghootkar, Hanieh 13 ; Zeng, Biao 15 ; Marioni, Riccardo E 37 ; Montgomery, Grant W 1
; Deary, Ian J 38 ; Wray, Naomi R 2
; Visscher, Peter M 2
; McRae, Allan F 1
; Yang, Jian 39
1 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
2 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
3 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia; The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
4 Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada
5 Department of Public Health Sciences, University of Chicago, Chicago, IL, USA
6 Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore
7 Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA
8 Heart Center Leipzig, Universität Leipzig, Leipzig, Germany
9 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands
10 Faculty of Genes, Behavior and Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
11 Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
12 Estonian Genome Center, University of Tartu, Tartu, Estonia
13 Exeter Medical School, University of Exeter, Exeter, UK
14 Department of Medicine, University of Washington, Seattle, WA, USA
15 School of Biological Sciences, Georgia Tech, Atlanta, GA, USA
16 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
17 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
18 National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland
19 Institute für Medizinische InformatiK, Statistik und Epidemiologie, LIFE–Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
20 IFB Adiposity Diseases, Department of Medicine, Universität Leipzig, Leipzig, Germany
21 Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany
22 Lausanne University Hospital, Lausanne, Switzerland
23 Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
24 Institut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE–Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
25 Institute of Genetic Epidemiology, Helmholtz Zentrum München, München, Germany
26 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
27 Institute of Human Genetics, Helmholtz Zentrum München, München, Germany
28 Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA, USA
29 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; University of Turku, Turku, Finland
30 School of Social and Community Medicine, University of Bristol, Bristol, UK
31 Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Solna, Sweden
32 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
33 Institute for Laboratory Medicine, LIFE–Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
34 Division of Endocrinology and Nephrology, Department of Medicine, Universität Leipzig, Leipzig, Germany
35 Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
36 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
37 Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
38 Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
39 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia; The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
; Wu, Yang 1
; Zeng, Jian 1
; Zhang, Futao 2 ; Xue, Angli 1 ; Jiang, Longda 1 ; Zhu, Zhihong 1 ; Kemper, Kathryn 1
; Yengo, Loic 1 ; Zheng, Zhili 3 ; Agbessi, Mawussé 4 ; Ahsan, Habibul 5 ; Alves, Isabel 4 ; Andiappan, Anand 6 ; Awadalla, Philip 4 ; Battle, Alexis 7 ; Beutner, Frank 8 ; Bonder, Marc Jan 9 ; Boomsma, Dorret 10 ; Christiansen, Mark 11 ; Claringbould, Annique 9 ; Deelen, Patrick 9 ; Tõnu Esko 12 ; Marie-Julie Favé 4 ; Franke, Lude 9 ; Frayling, Timothy 13 ; Gharib, Sina 14 ; Gibson, Gregory 15 ; Gibran Hemani 16 ; Jansen, Rick 10 ; Kähönen, Mika 17 ; Kalnapenkis, Anette 12 ; Silva Kasela 12 ; Kettunen, Johannes 18 ; Kim, Yungil 7 ; Kirsten, Holger 19 ; Kovacs, Peter 20 ; Krohn, Knut 21 ; Kronberg-Guzman, Jaanika 12 ; Kukushkina, Viktorija 12 ; Kutalik, Zoltan 22 ; Lee, Bernett 6 ; Lehtimäki, Terho 23 ; Loeffler, Markus 24 ; Marigorta, Urko M 15 ; Metspalu, Andres 12 ; Milani, Lili 12 ; Müller-Nurasyid, Martina 25 ; Nauck, Matthias 26 ; Nivard, Michel 10 ; Penninx, Brenda 10 ; Perola, Markus 18 ; Pervjakova, Natalia 12 ; Pierce, Brandon 5 ; Powell, Joseph 1 ; Prokisch, Holger 27 ; Psaty, Bruce 28 ; Raitakari, Olli 29 ; Ring, Susan 30 ; Ripatti, Samuli 18 ; Rotzschke, Olaf 6 ; Ruëger, Sina 22 ; Saha, Ashis 7 ; Scholz, Markus 24 ; Schramm, Katharina 25 ; Seppälä, Ilkka 23 ; Stumvoll, Michael 20 ; Sullivan, Patrick 31 ; Teumer, Alexander 32 ; Thiery, Joachim 33 ; Lin, Tong 5 ; Tönjes, Anke 34 ; Jenny van Dongen 10 ; Joyce van Meurs 35 ; Verlouw, Joost 35 ; Völker, Uwe 36 ; Võsa, Urmo 9 ; Yaghootkar, Hanieh 13 ; Zeng, Biao 15 ; Marioni, Riccardo E 37 ; Montgomery, Grant W 1
; Deary, Ian J 38 ; Wray, Naomi R 2
; Visscher, Peter M 2
; McRae, Allan F 1
; Yang, Jian 39
1 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
2 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
3 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia; The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
4 Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada
5 Department of Public Health Sciences, University of Chicago, Chicago, IL, USA
6 Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore
7 Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA
8 Heart Center Leipzig, Universität Leipzig, Leipzig, Germany
9 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands
10 Faculty of Genes, Behavior and Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
11 Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
12 Estonian Genome Center, University of Tartu, Tartu, Estonia
13 Exeter Medical School, University of Exeter, Exeter, UK
14 Department of Medicine, University of Washington, Seattle, WA, USA
15 School of Biological Sciences, Georgia Tech, Atlanta, GA, USA
16 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
17 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
18 National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland
19 Institute für Medizinische InformatiK, Statistik und Epidemiologie, LIFE–Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
20 IFB Adiposity Diseases, Department of Medicine, Universität Leipzig, Leipzig, Germany
21 Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany
22 Lausanne University Hospital, Lausanne, Switzerland
23 Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
24 Institut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE–Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
25 Institute of Genetic Epidemiology, Helmholtz Zentrum München, München, Germany
26 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
27 Institute of Human Genetics, Helmholtz Zentrum München, München, Germany
28 Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA, USA
29 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; University of Turku, Turku, Finland
30 School of Social and Community Medicine, University of Bristol, Bristol, UK
31 Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Solna, Sweden
32 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
33 Institute for Laboratory Medicine, LIFE–Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
34 Division of Endocrinology and Nephrology, Department of Medicine, Universität Leipzig, Leipzig, Germany
35 Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
36 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
37 Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
38 Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
39 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia; The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China
Pages
1-12
Publication year
2018
Publication date
Jun 2018
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2053307712
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.