Abstract

Cancer theragnosis agents with both cancer diagnosis and therapy abilities would be the next generation of cancer treatment. Recently, nanomaterials with strong absorption in near-infrared (NIR) region have been explored as promising cancer theragnosis agents for bio-imaging and photothermal therapy (PTT). Herein, we reported the synthesis and application of a novel multifunctional theranostic nanoagent based on hyaluronan (HA)-coated FeOOH@polypyrrole (FeOOH@PPy) nanorods (HA-FeOOH@PPy NRs) for photoacoustic imaging (PAI)-guided PTT. The nanoparticles were intentionally designed with rod-like shape and conjugated with tumor-targeting ligands to enhance the accumulation and achieve the entire tumor distribution of nanoparticles. The prepared HA-FeOOH@PPy NRs showed excellent biocompatible and physiological stabilities in different media. Importantly, HA-FeOOH@PPy NRs exhibited strong NIR absorbance, remarkable photothermal conversion capability, and conversion stability. Furthermore, HA-FeOOH@PPy NRs could act as strong contrast agents to enhance PAI, conducting accurate locating of cancerous tissue, as well as precise guidance for PTT. The in vitro and in vivo photothermal anticancer activity results of the designed nanoparticles evidenced their promising potential in cancer treatment. The tumor-bearing mice completely recovered after 17 days of PTT treatment without obvious side effects. Thus, our work highlights the great potential of using HA-FeOOH@PPy NRs as a theranostic nanoplatform for cancer imaging-guided therapy.

Details

Title
Photoacoustic Imaging-Guided Photothermal Therapy with Tumor-Targeting HA-FeOOH@PPy Nanorods
Author
Thi Tuong Vy Phan 1 ; Bui, Nhat Quang 2   VIAFID ORCID Logo  ; Soon-Woo, Cho 3 ; Subramaniyan Bharathiraja 4 ; Panchanathan Manivasagan 4 ; Madhappan Santha Moorthy 4 ; Mondal, Sudip 4 ; Chang-Seok, Kim 3 ; Oh, Junghwan 5   VIAFID ORCID Logo 

 Interdisciplinary Program of Biomedical Mechanical & Electrical Engineering, Pukyong National University, Busan, Republic of Korea; Center for Marine-Integrated Biomedical Technology, Pukyong National University, Busan, Republic of Korea 
 Interdisciplinary Program of Biomedical Mechanical & Electrical Engineering, Pukyong National University, Busan, Republic of Korea 
 Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, Republic of Korea 
 Center for Marine-Integrated Biomedical Technology, Pukyong National University, Busan, Republic of Korea 
 Interdisciplinary Program of Biomedical Mechanical & Electrical Engineering, Pukyong National University, Busan, Republic of Korea; Center for Marine-Integrated Biomedical Technology, Pukyong National University, Busan, Republic of Korea; Department of Biomedical Engineering, Pukyong National University, Busan, Republic of Korea 
Pages
1-13
Publication year
2018
Publication date
Jun 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2053308126
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.