Abstract

Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11–C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.

Details

Title
Synthesis and Cytotoxicities of Royleanone Derivatives
Author
Cheng-Ji, Li 1 ; Fan, Xia 1 ; Wu, Rong 2 ; Hong-Sheng, Tan 2 ; Hong-Xi, Xu 2 ; Xu, Gang 3 ; Hong-Bo, Qin 3   VIAFID ORCID Logo 

1  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, People’s Republic of China; University of Chinese Academy of Sciences, Beijing, People’s Republic of China 
2  Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China 
3  State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, People’s Republic of China 
Pages
453-456
Publication year
2018
Publication date
Dec 2018
Publisher
Springer Nature B.V.
ISSN
21922195
e-ISSN
21922209
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s13659-018-0173-y
ProQuest document ID
2056072412
Copyright
Natural Products and Bioprospecting is a copyright of Springer, (2018). All Rights Reserved., © 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.