Details
Title
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
Author
Kular, Lara 1 ; Liu, Yun 2 ; Ruhrmann, Sabrina 1 ; Zheleznyakova, Galina 1 ; Marabita, Francesco 1
; Gomez-Cabrero, David 3 ; Tojo, James 1 ; Ewing, Ewoud 1
; Lindén, Magdalena 1 ; Górnikiewicz, Bartosz 1 ; Aeinehband, Shahin 1 ; Stridh, Pernilla 1 ; Link, Jenny 1
; Andlauer, Till F M 4
; Gasperi, Christiane 5 ; Wiendl, Heinz 6 ; Zipp, Frauke 7
; Gold, Ralf 8 ; Tackenberg, Björn 9 ; Weber, Frank 10 ; Hemmer, Bernhard 11 ; Strauch, Konstantin 12 ; Heilmann-Heimbach, Stefanie 13 ; Rawal, Rajesh 14 ; Schminke, Ulf 15 ; Schmidt, Carsten O 16 ; Kacprowski, Tim 17
; Franke, Andre 18
; Laudes, Matthias 19 ; Dilthey, Alexander T 20 ; Celius, Elisabeth G 21 ; Søndergaard, Helle B 22 ; Tegnér, Jesper 23 ; Harbo, Hanne F 24 ; Oturai, Annette B 22 ; Olafsson, Sigurgeir 25 ; Eggertsson, Hannes P 25
; Halldorsson, Bjarni V 26
; Hjaltason, Haukur 27 ; Olafsson, Elias 27 ; Jonsdottir, Ingileif 28 ; Stefansson, Kari 29 ; Olsson, Tomas 1 ; Piehl, Fredrik 1 ; Ekström, Tomas J 1 ; Kockum, Ingrid 1 ; Feinberg, Andrew P 30
; Jagodic, Maja 1
1 Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
2 Center for Epigenetics, and Departments of Medicine, Biomedical Engineering and Mental Health, Johns Hopkins University, Baltimore, MD, USA; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education; Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China
3 Unit of Computational Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
4 Max Planck Institute of Psychiatry, Munich, Germany; Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany; German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
5 Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany; German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
6 German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany
7 German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Department of Neurology, University Medicine Mainz, Johannes Gutenberg University Mainz, Mainz, Germany
8 German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany
9 German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Neuroimmunology Center, Marburg University, Marburg, Germany
10 Max Planck Institute of Psychiatry, Munich, Germany; German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
11 Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany; German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
12 Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany and Institute of Medical Informatics, Biometry, and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
13 Institute of Human Genetics, University Hospital Bonn and Division of Genomics, Life & Brain Research Centre, University of Bonn School of Medicine, Bonn, Germany
14 Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany
15 Department of Neurology, University Medicine Greifswald, Greifswald, Germany
16 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
17 Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University and University Medicine Greifswald, Greifswald, Germany
18 Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany
19 Department I of Internal Medicine, Kiel University, Kiel, Germany
20 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Institute of Medical Microbiology and Hospital Hygiene Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
21 Department of Neurology, Oslo University Hospital, Oslo, Norway; Institute of Health and Society, Faculty of Medicine, University of Oslo, Olso, Norway
22 Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
23 Unit of Computational Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Biological and Environmental Sciences and Engineering Division, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
24 Department of Neurology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
25 deCODE genetics/Amgen Inc, Reykjavik, Iceland
26 deCODE genetics/Amgen Inc, Reykjavik, Iceland; School of Science and Engineering, Reykjavik University, Reykjavik, Iceland
27 Department of Neurology, Landspitali, The National University of Iceland, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
28 deCODE genetics/Amgen Inc, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Immunology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland
29 deCODE genetics/Amgen Inc, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
30 Center for Epigenetics, and Departments of Medicine, Biomedical Engineering and Mental Health, Johns Hopkins University, Baltimore, MD, USA
; Gomez-Cabrero, David 3 ; Tojo, James 1 ; Ewing, Ewoud 1
; Lindén, Magdalena 1 ; Górnikiewicz, Bartosz 1 ; Aeinehband, Shahin 1 ; Stridh, Pernilla 1 ; Link, Jenny 1
; Andlauer, Till F M 4
; Gasperi, Christiane 5 ; Wiendl, Heinz 6 ; Zipp, Frauke 7
; Gold, Ralf 8 ; Tackenberg, Björn 9 ; Weber, Frank 10 ; Hemmer, Bernhard 11 ; Strauch, Konstantin 12 ; Heilmann-Heimbach, Stefanie 13 ; Rawal, Rajesh 14 ; Schminke, Ulf 15 ; Schmidt, Carsten O 16 ; Kacprowski, Tim 17
; Franke, Andre 18
; Laudes, Matthias 19 ; Dilthey, Alexander T 20 ; Celius, Elisabeth G 21 ; Søndergaard, Helle B 22 ; Tegnér, Jesper 23 ; Harbo, Hanne F 24 ; Oturai, Annette B 22 ; Olafsson, Sigurgeir 25 ; Eggertsson, Hannes P 25
; Halldorsson, Bjarni V 26
; Hjaltason, Haukur 27 ; Olafsson, Elias 27 ; Jonsdottir, Ingileif 28 ; Stefansson, Kari 29 ; Olsson, Tomas 1 ; Piehl, Fredrik 1 ; Ekström, Tomas J 1 ; Kockum, Ingrid 1 ; Feinberg, Andrew P 30
; Jagodic, Maja 1 1 Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
2 Center for Epigenetics, and Departments of Medicine, Biomedical Engineering and Mental Health, Johns Hopkins University, Baltimore, MD, USA; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education; Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, China
3 Unit of Computational Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
4 Max Planck Institute of Psychiatry, Munich, Germany; Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany; German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
5 Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany; German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
6 German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany
7 German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Department of Neurology, University Medicine Mainz, Johannes Gutenberg University Mainz, Mainz, Germany
8 German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany
9 German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Neuroimmunology Center, Marburg University, Marburg, Germany
10 Max Planck Institute of Psychiatry, Munich, Germany; German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
11 Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technische Universität München, Munich, Germany; German Competence Network Multiple Sclerosis (KKNMS), Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
12 Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany and Institute of Medical Informatics, Biometry, and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
13 Institute of Human Genetics, University Hospital Bonn and Division of Genomics, Life & Brain Research Centre, University of Bonn School of Medicine, Bonn, Germany
14 Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany
15 Department of Neurology, University Medicine Greifswald, Greifswald, Germany
16 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
17 Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University and University Medicine Greifswald, Greifswald, Germany
18 Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany
19 Department I of Internal Medicine, Kiel University, Kiel, Germany
20 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Institute of Medical Microbiology and Hospital Hygiene Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
21 Department of Neurology, Oslo University Hospital, Oslo, Norway; Institute of Health and Society, Faculty of Medicine, University of Oslo, Olso, Norway
22 Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
23 Unit of Computational Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Biological and Environmental Sciences and Engineering Division, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
24 Department of Neurology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
25 deCODE genetics/Amgen Inc, Reykjavik, Iceland
26 deCODE genetics/Amgen Inc, Reykjavik, Iceland; School of Science and Engineering, Reykjavik University, Reykjavik, Iceland
27 Department of Neurology, Landspitali, The National University of Iceland, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
28 deCODE genetics/Amgen Inc, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Immunology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland
29 deCODE genetics/Amgen Inc, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
30 Center for Epigenetics, and Departments of Medicine, Biomedical Engineering and Mental Health, Johns Hopkins University, Baltimore, MD, USA
Pages
1-15
Publication year
2018
Publication date
Jun 2018
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2057096280
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.