Abstract

The study performed by Zhou et al. (World J Surg Oncol 15:104, 2017) titled “Clinical and prognostic significance of HIF-1α overexpression in oral squamous cell carcinoma: a meta-analysis” attempts to highlight hypoxia-inducible factor-1 alpha as a possible prognostic marker in oral squamous cell carcinoma (OSCC). We would like to underline a few points which may affect such a conclusion. The correlations between HIF-1α expression and tumour size as well as tumour stage are debatable. Further, the subgroup analysis incorporating Australia and Europe into a single subgroup limits the viability of the prognostic analysis of HIF-1α. We also suggest future studies in the same research area to analyse head and neck squamous cell carcinoma instead of OSCC, to ameliorate the limitations encountered by Zhou et al., due to the scarcity of relevant clinical data and a low number of studies about OSCC.

Details

Title
Letter to the editor: is HIF-1α a viable prognostic indicator in OSCC? A critical review of a meta-analysis study
Author
Jayaraj, Rama; Kumarasamy, Chellan; Royam, Madhav Madurantakam; Devi, Arikketh; Baxi, Siddharta
Publication year
2018
Publication date
2018
Publisher
BioMed Central
e-ISSN
14777819
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2057158279
Copyright
Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.