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Abstract
Transcriptional responses to extracellular stimuli involve tuning the rates of transcript production and degradation. Here, we show that the time-dependent profiles of these rates can be inferred from simultaneous measurements of precursor mRNA (pre-mRNA) and mature mRNA profiles. Transcriptome-wide measurements demonstrate that genes with similar mRNA profiles often exhibit marked differences in the amplitude and onset of their production rate. The latter is characterized by a large dynamic range, with a group of genes exhibiting an unexpectedly strong transient production overshoot, thereby accelerating their induction and, when combined with time-dependent degradation, shaping transient responses with precise timing and amplitude.
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Details
1 Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel
2 Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
3 Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
4 Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
5 Sheba Cancer Research Center, The Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
6 Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel; Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel