It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Similar results were obtained in experiments when cells were treated with HGF (32.6% versus 21.8%, P = 0.021 for A549; 36.8% versus 25.4%, P = 0.031 for H1299, respectively). [...]silencing expression of cortactin could result in reduction of invadopodia, which induced by PDBu or HGF (Fig. 5d and e). [...]the formation of invadopodia in NSCLC cells was suppressed. miR-182 negatively regulates invadopodia function and ECM degradation in lung cancer cells by inhibiting cortactin Invadopodia are involved in ECM proteolysis, allowing tumor cells to infiltrate the stroma and vasculature. [...]many key invadopodia proteins are also cortactin-binding partners, including N-WASP, WIP, dynamin, ASAP1/AMAP1, and Src kinase [40], suggesting that cortactin also acts as a scaffolding function in invadopodia. Functionally, decreased expression of cortactin was shown to decrease cell motility in a variety of assays, including transwell migration, wound closure, and cell motility. [...]our results indicated that cortactin expression was upregulated when lung cancer cells were treated with PDBu or HGF, as well as invadopodia formation in non-small cell lung cancer cells, which indicated an important role of cortactin in invadopodia formation.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer