The values of applying classification and counts of white blood cells to the prognostic evaluation of resectable gastric cancers

Abstract

According to the cancer statistics in 2017, new gastric cancer cases numbered almost 28,000, and more than 10,960 deaths were caused by gastric cancer in united states [2]. Masahiro Lida et al. found that the incidence of GC increased linearly with increasing count of total WBC [19]. [...]total WBC count was negatively related to the survival of GC, especially with H. pylori (HP) infection [19]. H. pylori infection has been shown to increase the production of reactive oxygen metabolites [20, 21], which often cause extensive tissue damage and DNA damage, leading to mutations of oncogenes and tumor suppressors [22, 23]. [...]the relationship between total WBC count and survival of GC could be a reflection of the extent of mucosal inflammation induced by H. pylori infection [24]. Existing researches have focused on the role of BA playing in parasite allergy, immediate hypersensitivity and autoimmunity [16]. [...]as a type of immune cells, BA is demonstrated to be negatively associated with outcomes of pancreatic cancer [53].