Overcoming challenges to dissemination and implementation of research findings in under-resourced countries

Abstract

First and foremost, the truthful reporting of results is emphasized as essential because both studies with desirable findings as well those with less than ideal results can provide new and valuable knowledge. While there is little disagreement about the benefits associated with the indicated outcomes of increasing rates of breastfeeding initiation, exclusivity for the first 6 months of an infant’s life, and continued duration for at least a year, not all babies are born into breastfeeding-friendly, hospital environments. [...]there is the need for more research to determine other cost-effective means to achieve behavioral change among mothers and caregivers and to confirm the necessary conditions to improve both infant and maternal breastfeeding outcomes. The study was designed to increase corticosteroids use among women who were at increased risk for a preterm birth. Since there was no debate about the efficacy of employing corticosteroids to reduce neonatal mortality in the developed world, this Global Network trial primarily focused on implementation and effectiveness. [...]it is recommended that clinical trials addressing effectiveness (as a component of translational research) retain sufficient flexibility and incorporate intermediate process evaluations, reflective of the changing needs of the end users.