Intrathoracic pressure regulation therapy applied to ventilated patients for treatment of compromised cerebral perfusion from brain injury

Abstract

[...]cerebral perfusion pressure was 16% higher during (81 ± 10) compared to before active intrathoracic pressure regulation (70 ± 14) (p = 0.04) and this effect remained present 30 minutes after therapy was discontinued. [...]improving the care of patients with BI is a major health issue. According to the Brain Trauma Foundation Guidelines, “Hypotension, occurring at any time from injury through the acute intensive care course, has been found to be a primary predictor of outcome from severe head injury for the health care delivery systems within which prognostic variables have been best studied. [...]the exact role of this approach whether it be utilized as a first-line defense, in combination with osmotic agents to reduce ICP, or whether it be utilized as a salvage therapy, has not been determined yet and further study will be necessary.