Abstract

High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vitro and in vivo T2 relaxivity for magnetic resonance imaging as compared to other types of Fe3O4-Au hybrids and commercial contrast agents. The nanoparticles provide two functional surfaces for theranostic applications. For the first time, Fe3O4-Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanoparticle vehicle and the drug cargo in vitro and in vivo. The delivery to tumors and payload release are demonstrated in real time by intravital microscopy. Replacing the dyes by cell-specific molecules and drugs makes the Fe3O4-Au hybrids a unique all-in-one platform for theranostics.

Details

Title
Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics
Author
Efremova, Maria V 1   VIAFID ORCID Logo  ; Naumenko, Victor A 2 ; Spasova, Marina 3 ; Garanina, Anastasiia S 1   VIAFID ORCID Logo  ; Abakumov, Maxim A 4 ; Blokhina, Anastasia D 5 ; Melnikov, Pavel A 6 ; Prelovskaya, Alexandra O 2 ; Heidelmann, Markus 7 ; Zi-An, Li 3 ; Zheng, Ma 3 ; Shchetinin, Igor V 2 ; Golovin, Yuri I 8 ; Kireev, Igor I 9   VIAFID ORCID Logo  ; Savchenko, Alexander G 2 ; Chekhonin, Vladimir P 10 ; Klyachko, Natalia L 1 ; Farle, Michael 3 ; Majouga, Alexander G 11 ; Wiedwald, Ulf 12   VIAFID ORCID Logo 

1  Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation; National University of Science and Technology «MISIS», Moscow, Russian Federation 
2  National University of Science and Technology «MISIS», Moscow, Russian Federation 
3  Faculty of Physics and Center for Nanointegration Duisburg-Essen, University of Duisburg-Essen, Duisburg, Germany 
4  National University of Science and Technology «MISIS», Moscow, Russian Federation; Department of Medical Nanobiotechnology, Russian National Research Medical University, Moscow, Russian Federation 
5  Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation 
6  Department of Fundamental and Applied Neurobiology, Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russian Federation 
7  ICAN - Interdisciplinary Center for Analytics on the Nanoscale and Center for Nanointegration Duisburg-Essen, University of Duisburg-Essen, Duisburg, Germany 
8  Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation; Derzhavin Tambov State University, Nanocenter, Tambov, Russian Federation 
9  A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation 
10  Department of Medical Nanobiotechnology, Russian National Research Medical University, Moscow, Russian Federation; Department of Fundamental and Applied Neurobiology, Serbsky National Medical Research Center for Psychiatry and Narcology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russian Federation 
11  Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation; National University of Science and Technology «MISIS», Moscow, Russian Federation; D. Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation 
12  National University of Science and Technology «MISIS», Moscow, Russian Federation; Faculty of Physics and Center for Nanointegration Duisburg-Essen, University of Duisburg-Essen, Duisburg, Germany 
Pages
1-19
Publication year
2018
Publication date
Jul 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-018-29618-w
ProQuest document ID
2076905261
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.