Full text

Turn on search term navigation

Copyright © 2018 Susanne Becker et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0/

Abstract

Pain elicits fear and anxiety and promotes escape, avoidance, and adaptive behaviors that are essential for survival. When pain persists, motivational priority and attention shift to pain-related information. Such a shift often results in impaired functionality, leading to maladaptive pain-related fear and anxiety and escape and avoidance behaviors. Neuroimaging studies in chronic pain patients have established that brain activity, especially in cortical and mesolimbic regions, is different from activity observed during acute pain in control subjects. In this review, we discuss the psychophysiological and neuronal factors that may be associated with the transition to chronic pain. We review information from human studies on neural circuits involved in emotional and motivational pain processing and how these circuits are altered in chronic pain conditions. We then highlight findings from animal research that can increase our understanding of the molecular and cellular mechanisms underlying emotional-motivational pain processing in the brain. Finally, we discuss how translational approaches incorporating results from both human and animal investigations may aid in accelerating the discovery of therapies.

Details

Title
Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research
Author
Becker, Susanne 1   VIAFID ORCID Logo  ; Navratilova, Edita 2 ; Nees, Frauke 1 ; Stefaan Van Damme 3 

 Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany 
 Department of Pharmacology, University of Arizona, Tucson, AZ, USA 
 Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium 
Editor
Filippo Brighina
Publication year
2018
Publication date
2018
Publisher
John Wiley & Sons, Inc.
ISSN
12036765
e-ISSN
19181523
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2078424638
Copyright
Copyright © 2018 Susanne Becker et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0/