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Abstract
The circular RNA ciRS-7 has been reported to be involved in the pathogenesis of various tumors, including gastric and colorectal cancer. However, the role of ciRS-7 in esophageal squamous cell carcinoma (ESCC) remains unsolved. In this study, we found that the ciRS-7 expression was significantly upregulated in ESCC cancer tissues compared with matched normal tissues and associated with poor patient survival. Overexpression of ciRS-7 abrogated the tumor-suppressive roles of miR-7 including cell proliferation, migration and invasion in vitro as well as tumor growth and lung metastasis in vivo. Mechanistically, ciRS-7 functioned as the sponge of miR-7 and reactivated its downstream HOXB13-mediated NF-κB/p65 pathway. Conclusively, our findings demonstrate how ciRS-7 induces malignant progression of ESCC and that ciRS-7 may act as a novel prognostic marker and therapeutic target for this lethal disease.
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Details
1 Department of General Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
2 Department of Emergency Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
3 Department of hematology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China
4 Department of Cardiovascular Medicine, Ezhou Central Hospital of Hubei, Ezhou, China