Comments on `Hydrogen bonds in crystalline d-alanine: diffraction and spectroscopic evidence for differences between enantiomers'

Abstract

The recent paper by Belo, Pereira, Freire, Argyriou, Eckert & Bordallo [(2018[Belo, E. A., Pereira, J. E. M., Freire, P. T. C., Argyriou, D. N., Eckert, J. & Bordallo, H. N. (2018). IUCrJ, 5, 6-12.]), IUCrJ, 5, 6–12] reports observations that may lead one to think of very strong and visible consequences of the parity-violation energy difference between enantiomers of a molecule, namely alanine. If proved, this claim would have an enormous impact for research in structural chemistry. However, alternative, more realistic, explanations of their experiments have not been ruled out by the authors. Moreover, the theoretical calculations carried out to support the hypothesis are unable to differentiate between enantiomers (molecules or crystals). Therefore, the conclusions drawn by Belo et al. (2018[Belo, E. A., Pereira, J. E. M., Freire, P. T. C., Argyriou, D. N., Eckert, J. & Bordallo, H. N. (2018). IUCrJ, 5, 6-12.]) are deemed inappropriate as the data presented do not contain sufficient information to reach such a conclusion.