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Copyright © 2018 Anacharis B. Sá-Nakanishi et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0/

Abstract

Methyl jasmonate (MeJA) is a fatty acid-derived cyclopentanone which shares structural similarities with prostaglandins and has been under study as a promising anti-inflammatory agent. This study investigated the actions of MeJA on systemic inflammation and oxidative status in rats with adjuvant-induced arthritis, a model for rheumatoid arthritis. MeJA (75 to 300 mg·kg−1) was administrated orally during 18 days after arthritis induction with Freund’s adjuvant. Articular and systemic inflammation was greatly increased in arthritic rats, likewise the oxidative stress in plasma and liver. The hepatic glucokinase activity and glycolysis were increased in arthritic rats. MeJA decreased most inflammatory parameters and abolished the increased protein carbonylation in plasma and liver, diminished the increased hepatic ROS content, and restored the hepatic GSH/GSSG ratio in arthritic rats. However, the MeJA treatment decreased the hepatic glucokinase activity and glycolysis and stimulated mitochondrial ROS production in healthy and arthritic rats. Oxygen uptake was increased by MeJA only in livers from treated arthritic rats. This action may bear relation to the increased activity of mitochondrial NADP+-dependent enzymes to provide reducing equivalents for the glutathione cycle. These beneficial effects, however, are associated with a decreased glucose flux through the glycolysis in the liver of arthritic and healthy rats.

Details

Title
Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats
Author
Sá-Nakanishi, Anacharis B 1 ; Soni-Neto, Jamil 1 ; Moreira, Lucas S 1 ; Gonçalves, Geferson A 1 ; Silva, Francielli M S 2   VIAFID ORCID Logo  ; Bracht, Lívia 1 ; Bersani-Amado, Ciomar A 2 ; Peralta, Rosane M 1   VIAFID ORCID Logo  ; Bracht, Adelar 1   VIAFID ORCID Logo  ; Comar, Jurandir F 1   VIAFID ORCID Logo 

 Department of Biochemistry, State University of Maringa, 87020900 Maringá-PR, Brazil 
 Department of Pharmacology and Therapeutics, State University of Maringa, 87020900 Maringá-PR, Brazil 
Editor
Jolanta Czuczejko
Publication year
2018
Publication date
2018
Publisher
John Wiley & Sons, Inc.
ISSN
19420900
e-ISSN
19420994
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2098670841
Copyright
Copyright © 2018 Anacharis B. Sá-Nakanishi et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0/