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© 2018. This work is licensed under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Objective: Brain metastasis is considered rare in metastatic colorectal cancer (mCRC); thus, surveillance imaging does notroutinely include the brain. The reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods: The South Australian mCRC Registry (SAmCRC) was analyzed to assess the number of patients presenting with brainmetastasis during their lifetime. Due to small numbers, a descriptive analysis is presented.Results: Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis (1.4%). The clinicalcharacteristics of those with brain metastasis were as follows: the median age was 65.3 years and 51% were female. Where the VKi-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation status of the tumor was known, the majority harbored aKRAS mutation (55%); 31 (53%) underwent craniotomy and 55 (93%) underwent whole-brain radiotherapy. The median survivaltime from diagnosis of brain metastasis was 4.2 months (95% confidence interval 2.9–5.5). Patients who underwent craniotomyand radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy (8.5 months vs. 2.2 months,respectively). Data from the SAmCRC (a population-based registry) confirm that brain metastases are rare and the median time todevelopment is approximately 2 years.Conclusions: Brain metastasis is a rare outcome in advanced CRC. Patients within the registry tended to be female, young in age,and harbored with higher rates of KRAS mutations. Whether routine surveillance brain scanning should be considered remainscontroversial given the relative rarity of developing brain metastases in mCRC and ultimately, most patients with central nervoussystem involvement die from their extracranial disease.

Details

Title
Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry
Author
Gonzalo Tapia Rico; Price, Timothy J; Karapetis, Christos; Piantadosi, Cynthia; Padbury, Rob; Roy, Amitesh; Maddern, Guy; Moore, James; Carruthers, Scott; Roder, David; Townsend, Amanda R
Pages
371-376
Section
Original Article
Publication year
2017
Publication date
May 2017
Publisher
Chinese Anti-Cancer Association (CACA), Cancer Biology & Medicine
ISSN
20953941
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2102439801
Copyright
© 2018. This work is licensed under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.