Abstract

Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.

Details

Title
A comprehensive manually-curated compendium of bovine transcription factors
Author
de Souza, Marcela M 1 ; Zerlotini, Adhemar 2   VIAFID ORCID Logo  ; Ludwig Geistlinger 3 ; Tizioto, Polyana C 4 ; Taylor, Jeremy F 5   VIAFID ORCID Logo  ; Rocha, Marina I P 6 ; Diniz, Wellison J S 6   VIAFID ORCID Logo  ; Coutinho, Luiz L 7   VIAFID ORCID Logo  ; Regitano, Luciana C A 3   VIAFID ORCID Logo 

1  Post-graduation Program of Evolutionary Genetics and Molecular Biology, Federal University of São Carlos, São Carlos, São Paulo, Brazil; Animal Biotechnology, Embrapa Pecuária Sudeste, São Carlos, São Paulo, Brazil 
2  Bioinformatic Multi-user Laboratory, Embrapa Informática Agropecuária, Campinas, São Paulo, Brazil 
3  Animal Biotechnology, Embrapa Pecuária Sudeste, São Carlos, São Paulo, Brazil 
4  NGS Genomic Solutions, Piracicaba, São Paulo, Brazil 
5  Division of Animal Science, University of Missouri, Columbia, Missouri, USA 
6  Post-graduation Program of Evolutionary Genetics and Molecular Biology, Federal University of São Carlos, São Carlos, São Paulo, Brazil 
7  Functional Genomic Center, University of São Paulo, Piracicaba, São Paulo, Brazil 
Pages
1-12
Publication year
2018
Publication date
Sep 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-018-32146-2
ProQuest document ID
2103659009
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.