Abstract

Deposition of bioactive coatings composed of zinc oxide, cyclodextrin and cefepime (ZnO/CD/Cfp) was performed by the Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The obtained nanostructures were characterized by X-ray diffraction, IR microscopy and scanning electron microscopy. The efficient release of cefepime was correlated with an increased anti-biofilm activity of ZnO/CD/Cfp composites. In vitro and in vivo tests have revealed a good biocompatibility of ZnO/CD/Cfp coatings, which recommend them as competitive candidates for the development of antimicrobial surfaces with biomedical applications. The release of the fourth generation cephalosporin Cfp in a biologically active form from the ZnO matrix could help preventing the bacterial adhesion and the subsequent colonization and biofilm development on various surfaces, and thus decreasing the risk of biofilm-related infections.

Details

Title
Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces
Author
Oprea, Alexandra Elena; Pandel, Loredana Mihaela; Dumitrescu, Ana Maria; Andronescu, Ecaterina; Grumezescu, Valentina; Chifiriuc, Mariana Carmen; Mogoantă, Laurenţiu; Tudor-Adrian Bălşeanu; George Dan Mogoşanu; Socol, Gabriel; Alexandru Mihai Grumezescu; Iordache, Florin; Maniu, Horia; Chirea, Mariana; Holban, Alina Maria
First page
220
Publication year
2016
Publication date
2016
Publisher
MDPI AG
e-ISSN
14203049
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2108545591
Copyright
© 2016. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.