Abstract

A comprehensive comparative evaluation of the ability of L-17 compound (2-morpholino-5- phenyl-1,3,4-thiadiazine) and antioxidant lipoic acid (LA) to correct blood cytokine levels, metabolic disordersand morphological alterations in pancreas in alloxan-induced diabetes was performed for the first time, using an experimental in vivo model. All the tested compounds have been found to correct hyperglycemia and decreased accumulation of glycated blood proteins. The tested L-17 compound belongs to the 1,3,4-thiadiazine series and is able to correct metabolic disorders occurring in alloxan-induced diabetes comparable to activity of LA antioxidant. However, L-17 reduces the cytokine levels to the values of intact animals, that preventing development of systemic inflammatory response which causes damage of target organs in diabetes mellitus.

Details

Title
CYTOKINE REGULATION OF REGENERATIVE PROCESSES IN PANCREATIC GLAND IN ALLOXAN-INDUCED DIABETIC RATS, AND IT CORRECTION BY 1,3,4-THIADIAZINE COMPOSITION AND LIPOIC ACID
Author
Danilova, I G; Emelianov, V V; Gette, I F; S Yu Medvedeva; Bulavintseva, T S; Chereshneva, M V; Sidorova, L P; Chereshnev, V A; Sokolova, K V
Pages
35-44
Section
ORIGINAL ARTICLES
Publication year
2018
Publication date
2018
Publisher
Russian Association of Allerologists and Clinical Immuniologists, St. Petersburg Branch
ISSN
15630625
e-ISSN
2313741X
Source type
Scholarly Journal
Language of publication
Russian
ProQuest document ID
2109431701
Copyright
© 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.