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Copyright © 2018 Shelly N. Hester et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0/

Abstract

Background. Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem. Objectives. An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin and prebiotic blend in modulating intestinal microbiota and intestinal inflammation. Results. After 8 weeks of daily supplementation, participants had a significant decrease in Firmicutes (p<0.001) and Actinobacteria (p<0.001) and a significant increase in Bacteroidetes (p<0.001). Bowel habits were improved as evidenced by reductions in the severity of bloating (p<0.05), gas (p=0.035), and abdominal pain (p=0.015) as well as significant improvements in stool consistency (p<0.05). Finally, a nonsignificant decrease in the inflammatory marker fecal calprotectin was seen (p=0.107). The supplement was safe and well tolerated. Conclusions. The results suggest that regular consumption of the anthocyanin-prebiotic blend positively modulated the intestinal ecosystem and provided insights into the mechanisms of action and its impact on health benefits.

Details

Title
Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects
Author
Hester, Shelly N 1   VIAFID ORCID Logo  ; Mastaloudis, Angela 1 ; Gray, Russell 1 ; Antony, Joseph M 2 ; Evans, Mal 2 ; Wood, Steven M 1   VIAFID ORCID Logo 

 Pharmanex Research, NSE Products Inc., 75 West Center Street, Provo, UT 84601, USA 
 KGK Science Inc., 255 Queens Avenue, Suite 1440, London, Ontario, Canada N6A 5R8, 
Editor
Luigi Schiavo
Publication year
2018
Publication date
2018
Publisher
John Wiley & Sons, Inc.
ISSN
20900724
e-ISSN
20900732
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2111092619
Copyright
Copyright © 2018 Shelly N. Hester et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0/