Abstract
[1] Extensive hepatic necrosis, coagulopathy, impaired liver synthetic function, and hepatic encephalopathy define acute liver failure. Acute Liver Failure (ALF) etiology encompasses a variety of toxic, viral, metabolic and vascular insults as well as DILI, which may manifest especially in perioperative patients who receive multiple medications with hepatotoxic potential. [4] On further analysis of the case and based on the clinical factors analyzed, the likelihood of possible volatile-induced ALF is high (based on the suspicion of drug-induced liver injury with negative exposure or autoimmune panel and suggestive liver biopsy features).
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Details
1 Department of Anesthesia, Pain Management and Perioperative Medicine, Henry Ford Hospital, Detroit, Michigan
2 Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, Michigan
3 Division of Critical Care, Department of Anesthesia, Pain Management and Perioperative Medicine, Henry Ford Hospital, Detroit, Michigan